Table 2 ABC transporter gene polymorphisms of doxorubicin involved in human placenta [40,41,42,43]
From: Maternal ABVD chemotherapy for Hodgkin lymphoma in a dichorionic diamniotic pregnancy: a case report
Transporter | Syncytiotrophoblast localization | Variant | Modulation on disposition of doxorubicin | Modulation on cardiotoxicity of doxorubicin |
|---|---|---|---|---|
ABCB1 (P-gp) | Apical | 1236C > T | Higher maximum plasma concentration, higher AUC in T carriers | No data |
Haplotype 1236TT 2677TT 3435TT | Higher plasma concentrations in TT carriers | No data | ||
ABCG2 | Apical | 421C > A | No significant impact on doxorubicin pharmacokinetics | No data |
ABCC1 (MRP1) | Apical | 2012G > T | No data | Higher acute cardiotoxicity in T carriers |
ABCC2 | Apical | 3563 T > A 4544G > A | No data | Higher acute cardiotoxicity in A carriers |
ABCC5 | Basolateral | 1679 T > A | Higher doxorubicinol exposure in TT carriers | No data |