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Table 3 Comparison of baseline characteristics and pregnancy outcomes in twin pregnancies with large (≥5 cm), small (< 5 cm), or without uterine fibroid(s) (UFs)

From: Twin pregnancies with uterine fibroids are not at increased risk for obstetric complications: single center cohort study

Variables

Group A

Twin pregnancies

with ≥5 cm UFs (n = 32)

Group B

Twin pregnancies with < 5 cm UFs (n = 159)

Group C

Twin pregnancies

without UFs (n = 1077)

A vs B vs C

p-value

A vs B

p-value

A vs C

p-value

B vs C

p-value

Maternal age (year)

34.9 ± 3.7

35.2 ± 3.1

33.9 ± 3.1

< 0.001

0.279

0.263

< 0.001

(34, 30–44)

(35, 24–43)

(34, 23–45)

    

BMI at delivery (kg/m2)

27.0 ± 3.2

27.0 ± 2.8

26.9 ± 3.1

0.886

0.652

0.646

0.864

(26.7, 19.3–34.1)

(26.6, 20.6–35.2)

(26.6, 18–39.3)

    

Medical history, number (%)

Prepregnancy HTN

0 (0%)

2 (1.3%)

10 (0.9%)

0.789

1.0

1.0

0.660

Prepregnancy diabetes

0 (0%)

2 (1.3%)

3 (0.3%)

0.173

1.0

1.0

0.127

Primiparity

31 (96.9%)

146 (91.8%)

917 (85.1%)

0.015

0.472

0.073

0.027

Previous preterm birth

0 (0%)

2 (1.3%)

14 (1.3%)

0.810

1.0

1.0

1.0

Mode of conception

   

0.609

0.470

0.601

0.438

Natural or TI, COH + TI

5 (15.6%)

18 (11.3%)

163 (15.1%)

    

IUI or COH + IUI

1 (3.1%)

14 (8.8%)

86 (8.0%)

    

IVF or T-ET

26 (81.3%)

127 (79.9%)

828 (76.9%)

    

Chorionicity

   

0.113

0.113

0.049

0.760

Monochorionic

6 (18.7%)

14 (8.8%)

89 (8.3%)

    

Dichorionic

26 (81.3%)

145 (91.2%)

988 (91.7%)

    

GA at delivery (weeks)

36.2 ± 1.8

36.0 ± 2.3

36.1 ± 2.1

0.867

0.833

0.889

0.602

(36.9, 31.3–38.3)

(36.9, 22.6–38.9)

(36.9, 22.1–39.4)

    

Sum of birth weight of twina

4794.1 ± 628.9

4767.6 ± 877.2

4846.8 ± 811.5

0.259

0.837

0.361

0.156

(4810, 3410–5950)

(4810, 1172–6920)

(4970,844, 6710)

    

Weight difference of twina

331.6 ± 236.3

299.3 ± 241.2

284.8 ± 227.5

0.401

0.383

0.202

0.587

(255, 0–990)

(260, 10–1310)

(230, 0–1390)

    

Delivery < 37 weeks

19 (59.4%)

84 (52.8%)

592 (55.0%)

0.767

0.563

0.719

0.670

Delivery < 34 weeks

4 (12.5%)

20 (12.6%)

115 (10.7%)

0.744

1.0

0.769

0.495

Preterm labor

15 (46.9%)

63 (39.6%)

461 (42.8%)

0.660

0.555

0.718

0.492

Admission d/t preterm labor

9 (28.1%)

39 (24.5%)

299 (27.8%)

0.691

0.660

1.0

0.446

PPROM

5 (15.6%)

25 (15.7%)

167 (15.5%)

0.997

1.0

1.0

0.907

Pre-eclampsia

3 (9.4%)

19 (11.9%)

98 (9.1%)

0.518

1.0

1.0

0.247

Gestational diabetes

4 (12.5%)

21 (13.2%)

91 (8.4%)

0.121

1.0

0.346

0.055

Placenta previa

0 (0%)

6 (3.8%)

34 (3.2%)

0.537

0.592

0.621

0.632

IIOC

1 (3.1%)

4 (2.5%)

42 (3.9%)

0.679

1.0

1.0

0.504

>2nd trimester IUFD

0 (0%)

2 (1.3%)

16 (1.5%)

0.742

1.0

1.0

1.0

SGA (< 10%)a

5 (15.6%)

29 (18.2%)

165 (15.6%)

0.646

0.806

1.0

0.351

Placenta abruption

0 (0%)

2 (1.3%)

9 (0.8%)

0.750

1.0

1.0

0.642

Postpartum hemorrhage

3 (9.4%)

7 (4.4%)

64 (5.9%)

0.510

0.376

0.436

0.583

Peripartum transfusion

4 (12.5%)

12 (7.5%)

109 (10.1%)

0.525

0.315

0.559

0.390

Peripartum ICU care

2 (6.3%)

21 (13.2%)

124 (11.5%)

0.521

0.378

0.570

0.511

  1. aIUFD cases excluded (Group A, n = 32; Group B, n = 157, Group G, n = 1061). BMI body mass index, HTN hypertension, TI timed intercourse, COH controlled ovarian hyperstimulation, IUI intrauterine insemination, IVF in vitro fertilization, T-ET thawing-embryo transfer, GA gestational age, IUFD intrauterine fetal death, d/t due to, PPROM preterm premature rupture of membranes, IIOC incompetent internal os of cervix, SGA small for gestational age, ICU intensive care unit
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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