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Table 5 Screening accuracy of the PHQ-2* during pregnancy and postpartum using the EPDS as reference standard for at least probable minor depression

From: Comparison of screening accuracy of the Patient Health Questionnaire-2 using two case-identification methods during pregnancy and postpartum

 

Antepartum

n

%

(95% CI)

Baseline

n = 303

36-weeks

n = 275

 

Positive

≥ 2

≥ 3

Positive

≥ 2

≥ 3

True positive

12

12

6

12

12

6

False negative

0

0

6

0

0

6

True negative

200

254

283

157

217

249

False positive

91

37

8

106

46

14

Sensitivity

1.0

(0.76–1.0)

1.0

(0.76–1.0)

0.50

(0.25–0.75)

1.0

(0.76–1.0)

1.0

(0.76–1.0)

0.50

(0.25–0.75)

Specificity

0.69

(0.63–0.74)

0.87

(0.83–0.91)

0.97

(0.95–0.99)

0.60

(0.54–0.65)

0.83

(0.78–0.87)

0.95

(0.91–0.97)

PPV

0.12

(0.07–0.19)

0.25

(0.15–0.38)

0.43

(0.21–0.67)

0.10

(0.06–0.17)

0.21

(0.12–0.33)

0.30

(0.15–0.52)

NPV

1.0

(0.98–1.0)

1.0

(0.99–1.0)

0.98

(0.96–0.99)

1.0

(0.98–1.0)

1.0

(0.98–1.0)

0.98

(0.95–0.99)

+LR

3.20

(2.70–3.79)

7.87

(5.82–10.63)

18.52

(7.49–44.17)

2.48

(2.14–2.87)

5.71

(4.40–7.43)

9.4

(4.39–20.12)

-LR

0

-

0

-

0.51

(0.29–0.91)

0

-

0

-

0.53

(0.30–0.93)

Postpartum

 

6-weeks

n = 252

26-weeks

n = 227

 

Positive

≥ 2

≥ 3

Positive

≥ 2

≥ 3

True positive

27

24

13

26

19

6

False negative

6

9

20

6

13

26

True negative

163

193

213

144

179

191

False positive

56

26

6

51

16

4

Sensitivity

0.82

(0.66–0.91)

0.73

(0.56–0.85)

0.39

(0.25–0.56)

0.81

(0.65–0.91)

0.59

(0.42–0.75)

0.19

(0.09–0.35)

Specificity

0.74

(0.68–0.80)

0.88

(0.83–0.92)

0.97

(0.94–0.99)

0.74

(0.67–0.80)

0.92

(0.87–0.95)

0.98

(0.95–0.99)

PPV

0.33

(0.23–0.43)

0.48

(0.35–0.62)

0.68

(0.46–0.85)

0.34

(0.24–0.45)

0.54

(0.38–0.70)

0.60

(0.31–0.83)

NPV

0.96

(0.93–0.98)

0.96

(0.92–0.98)

0.91

(0.87–0.94)

0.96

(0.92–0.98)

0.93

(0.89–0.96)

0.88

(0.83–0.92)

+LR

3.20

(2.43–4.22)

6.11

(4.04–9.30)

14.59

(5.87–35.21)

3.10

(2.33–4.15)

7.24

(4.18–12.54)

8.95

(2.73–30.61)

-LR

0.25

(0.12–0.51)

0.31

(0.18–0.54)

0.62

(0.47–0.82)

0.25

(0.12–0.53)

0.44

(0.29–0.67)

0.83

(0.70–0.98)

  1. *Scoring method at cut-point ≥ 2 and ≥ 3 and categorical method (positive response to either or both questions)