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Table 4 Screening accuracy of the PHQ-2* during pregnancy and postpartum using the EPDS as reference standard for probable major depression

From: Comparison of screening accuracy of the Patient Health Questionnaire-2 using two case-identification methods during pregnancy and postpartum

 

Antepartum

n

%

(95% CI)

Baseline

n = 303

36-weeks

n = 275

 

Positive

≥ 2

≥ 3

Positive

≥ 2

≥ 3

True positive

7

7

4

5

5

3

False negative

0

0

3

0

0

2

True negative

200

254

286

157

217

253

False positive

96

42

10

113

53

17

Sensitivity

1.0

(0.65–1.0)

1.0

(0.65–1.0)

0.57

(0.25–0.84)

1.0

(0.57–1.0)

1.0

(0.57–1.0)

0.60

(0.23–0.88)

Specificity

0.68

(0.62–0.73)

0.86

(0.81–0.89)

0.97

(0.94–0.98)

0.58

(0.52–0.64)

0.80

(0.75–0.85)

0.94

(0.90–0.96)

PPV

0.07

(0.03–0.13)

0.14

(0.07–0.27)

0.29

(0.12–0.55)

0.04

(0.02–0.10)

0.09

(0.04–0.19)

0.15

(0.05–0.36)

NPV

1.0

(0.98–1.0)

1.0

(0.99–1.0)

0.99

(0.97–1.0)

1.0

(0.98–1.0)

1.0

(0.98–1.0)

0.99

(0.97–1.00)

+LR

3.09

(2.62–3.63)

7.04

(5.33–9.33)

16.79

(6.98–40.97)

2.39

(2.08–2.75)

5.10

(4.00–6.49)

9.52

(4.07–22.31)

-LR

0

-

0

-

0.44

(0.19–1.04)

0

-

0

-

0.43

(0.15–1.25)

Postpartum

 

6-weeks

n = 252

26-weeks

n = 227

 

Positive

≥ 2

≥ 3

Positive

≥ 2

≥ 3

True positive

14

14

11

13

12

5

False negative

0

0

3

1

2

9

True negative

169

202

230

149

190

208

False positive

69

36

8

64

23

5

Sensitivity

1.00

(0.79–1.00)

1.00

(0.79–1.00)

0.79

(0.52–0.92)

0.93

(0.69–0.99)

0.86

(0.60–0.96)

0.36

(0.16–0.61)

Specificity

0.71

(0.65–0.76)

0.85

(0.80–0.89)

0.97

(0.94–0.98)

0.70

(0.64–0.76)

0.89

(0.84–0.93)

0.98

(0.95–0.99)

PPV

0.17

(0.10–0.26)

0.28

(0.18–0.42)

0.58

(0.36–0.77)

0.17

(0.10–0.27)

0.34

(0.21–0.51)

0.50

(0.24–0.76)

NPV

1.00

(0.98–1.00)

1.00

(0.98–1.0)

0.99

(0.96–1.0)

0.99

(0.96–1.00)

0.99

(0.96–1.00)

0.96

(0.92–0.98)

+LR

3.45

(2.83–4.21)

6.62

(4.89–8.93)

23.12

(11.22–48.70)

3.10

(2.40–3.97)

7.94

(5.11–12.34)

15.52

(4.99–46.42)

-LR

0

-

0

-

0.22

(0.08–0.61)

0.10

(0.02–0.68)

0.16

(0.04–0.58)

0.66

(0.45–0.97)

  1. *Scoring method at cut-point ≥ 2 and ≥ 3 and categorical method (positive response to either or both questions)