Comparison of screening accuracy of the Patient Health Questionnaire-2 using two case-identification methods during pregnancy and postpartum

Table 2 Frequency of women with depression^±, and case-identification using two methods* on the PHQ-2

	Pregnancy		Postpartum
	Baseline n = 303	36-weeks n = 275	6-weeks n = 252	26-weeks n = 227
	n	n	n	n
	%	%	%	%
	(95% CI)	(95% CI)	(95% CI)	(95% CI)
Probable major depression^±	7	5	14	14
	2.3	1.8	5.6	6.2
	(0.9–4.7)	(0.6–4.2)	(3.1–9.2)	(3.4–10.1)
At least probable minor depression^±	12 4.0	12 4.4	33 13.1	32 14.1
At least probable minor depression^±	(2.1–6.8)	(2.3–7.5)	(9.2–17.9)	(9.9–19.3)
PHQ-2 total score ≥ 2	49	58	50	35
	16.2	21.1	19.8	15.4
	(12.2–20.8)	(16.4–26.4)	(15.1–25.3)	(11.0–20.8)
PHQ-2 total score ≥ 3	14	20	19	10
	4.6	7.3	7.5	4.4
	(2.6–7.6)	(4.5–11.0)	(4.6–11.5)	(2.1–8.0)
PHQ-2 Screen positive	103	118	83	77
	33.9	42.9	32.9	33.9
	(28.7–39.6)	(37.0–49.0)	(27.2–39.1)	(27.8–40.5)
Anhedonia^a (no depressed mood)	80	96	61	52
	26.4	34.9	24.2	22.9
	(21.5–31.8)	(29.3–40.9)	(19.1–30.0)	(17.6–28.9)
Depressed mood^b (no anhedonia)	68	71	68	57
	22.4	25.8	27.0	25.1
	(17.9–27.6)	(20.8–31.4)	(21.6–32.9)	(19.6–31.3)
Depressed mood and anhedonia^c	45	49	46	32
	14.9	17.8	18.3	14.1
	(11.0–19.4)	(13.5–22.9)	(13.7–23.6)	(9.9–19.3)

95% CI: 95% confidence interval for a sample proportion with binomial (Clopper Pearson) exact
^±Probable major depression: EPDS cut-off score ≥ 15 during pregnancy and ≥ 13 postpartum; At least probable minor depression: EPDS cut-off score ≥ 13 in pregnancy and ≥ 10 postpartum
*PHQ-2: Total score method with two cut-points (≥ 2 and ≥ 3); Categorical method: Screen positive to either Question 1 OR Question 2
**PHQ-2 Question completion: Categories of positive responses on PHQ-2 questions
^aPositive response to PHQ-2 Question 1 and negative response on question 2
^bPositive response to PHQ-2 Question 2 and negative response to question 1
^cPositive response to PHQ-2 Question 1 and question 2

ISSN: 1471-2393