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Table 4 Multivariate logistic regression analysis (Stepwise Forward Wald) for subsequent events of APO with each of the early pregnancy variables in 1163 pregnant women

From: Serum homocysteine and folate concentrations in early pregnancy and subsequent events of adverse pregnancy outcome: the Sichuan Homocysteine study

Variables

Odds ratio

95% CI

Wald

P value

Hcy

 I quartile

1

–

–

–

 II quartile

1.03

0.74–1.45

0.04

0.852

 III quartile

1.26

0.90–1.76

1.82

0.178

 IV quartile

5.89

4.08–8.51

89.09

< 0.001

Folate

 I quartile

1

–

–

–

 II quartile

0.71

0.50–1.00

3.96

0.047

 III quartile

0.45

0.32–0.63

21.17

< 0.001

 IV quartile

0.35

0.25–0.50

34.14

< 0.001

SBP

 I quartile

1

–

–

–

 II quartile

1.27

0.90–1.80

1.83

0.176

 III quartile

1.30

0.92–1.84

2.19

0.139

 IV quartile

1.89

1.33–2.68

12.47

< 0.001

DBP

 I quartile

1

–

–

–

 II quartile

1.08

0.77–1.52

0.19

0.660

 III quartile

1.34

0.95–1.89

2.84

0.092

 IV quartile

1.69

1.20–2.38

9.00

0.003

BMI

 I quartile

1

–

–

–

 II quartile

1.14

0.81–1.60

0.53

0.467

 III quartile

1.41

1.00–1.98

3.86

0.049

 IV quartile

1.83

1.30–2.58

11.86

0.001

Age

 I quartile

1

–

–

–

 II quartile

0.88

0.63–1.24

0.54

0.463

 III quartile

1.17

0.84–1.65

0.85

0.356

 IV quartile

1.52

1.08–2.14

5.75

0.016

Folate supplementation

0.55

0.35–0.86

6.72

0.010

  1. The 15 variables included in the model were as follows: Hcy, folate, VB12, TC, TG, LDL-C, HDL-C, FPG, UA, SBP, DBP, BMI and age, folate supplementation, and VB12 supplementation according to the results of the univariate logistic regression analysis. Of these, VB12, TC, TG, LDL-C, HDL-C, FPG, UA, and VB12 supplementation were rejected by the multivariate logistic regression analysis