Table 1 Principal characteristics of 1163 early pregnant women at 11–12 gestational weeks according to subsequent events of APO and non-APO

Hcy (μmol/L)

7.98 (7.03–12.60)

8.43 (7.16–14.27)

7.79 (6.90–8.34)

Folate (nmol/L)

21.43 (18.31–29.25)

20.26 (17.04–27.24)

23.80 (19.48–30.24)

VB12 (pmol/L)

401.28 (255.81–546.90)

377.68 (233.03–541.13)

414.63 (269.85–548.17)

hs-CRP (mg/L)

3.74 (1.68–9.21)

4.15 (1.56–9.57)

3.59 (1.68–8.49)

IL-6 (pg/mL)

37.28 (23.64–74.57)

37.87 (24.29–74.57)

36.80 (22.95–73.23)

TC (mmol/L)

5.34 ± 1.20

5.46 ± 1.31

5.23 ± 1.08

TG (mmol/L)

1.92 ± 1.05

1.97 ± 1.10

1.87 ± 1.01

LDL-C (mmol/L)

3.08 ± 1.01

3.19 ± 1.09

2.97 ± 0.91

HDL-C (mmol/L)

1.38 ± 0.35

1.33 ± 0.39

1.43 ± 0.31

FPG (mmol/L)

4.79 ± 1.36

4.91 ± 1.57

4.67 ± 1.13

UA (μmol/L)

318.31 ± 58.50

318.97 ± 59.15

317.69 ± 57.92

Age (years)

28.86 ± 5.25

29.69 ± 5.94

28.02 ± 4.38

SBP (mmHg)

127.99 ± 16.20

129.68 ± 17.46

126.39 ± 14.77

DBP (mmHg)

82.08 ± 8.11

83.19 ± 8.92

81.04 ± 7.12

BMI (kg/m²)

21.82 ± 3.12

22.23 ± 3.12

21.44 ± 3.08

Age over 35y (%)

15.05

19.54

10.83

Folate supplementation (%)

88.22

82.77

93.33

VB12 supplementation (%)

82.55

80.11

84.83

Smoking (%)

2.06

2.49

1.67

Excessive drinking (%)

3.96

3.73

4.17

Hypercholesterolemia (%)

15.56

20.25

11.17

Hypertriglyceridemia (%)

20.46

22.56

18.50

Low HDL-C (%)

13.50

18.65

8.67

High LDL-C (%)

19.00

25.04

13.33

Gestational diabetes (%)

8.34

10.30

6.50

Hypertension (%)

11.26

14.21

8.50

Underweight (%)

5.16

4.80

5.50

Overweight and obesity (%)

18.40

21.31

15.67