Study | Population Origin | Groups | VDR SNVs* | Conclusions |
---|---|---|---|---|
Manzon et al. (2013) [17] | Israel (Jewish) | 33 caucasian mothers and their PTN (24–35 weeks gestation) 98 mothers and their FTN | TaqI BsmI ApaI FokI | The frequency of the FokI/C allele was significantly higher in mothers who had preterm births. |
Cai et al. (2016) [18] | China | 57 mothers who had PTN 84 mothers who had FTN | FokI | The FokI/FF genotype was associated as a risk factor for preterm birth. |
Baczyńska-Strzecha et al. (2016) [19] | Poland | 100 caucasian mothers who had PTN (22–36.6 weeks gestation) 99 mothers who had FTN | TaqI BsmI ApaI | There was no difference in the frequency of the genotypes individually, but the combination of the genotypes BsmI/bb-ApaI/AA-TaqI/TT and BsmI/BB-ApaI/aa-TaqI/tt were more frequent in mothers who had preterm birth. |
Rosenfeld et al. (2017) [20] | Israel (Jewish) | 146 caucasian mothers and their PTN (24–36 weeks gestation) 229 mothers and their FTN | TaqI BsmI ApaI FokI | The ApaI/AA genotype was associated with an increased risk of preterm birth. |
Javorski et al. (2018) [21] | Brazil (Northeast) | 104 mothers who had PTN 85 mothers who had FTN | FokI | The FokI/T allele was associated with a higher risk of preterm birth. |
Barchitta et al. (2018) [22] | Italy | 17 mothers and their PTN (< 37 weeks gestation) 187 mothers and their FTN | FokI | The FokI polymorphic genotype in mothers was associated with an increased risk for preterm birth. |
This study | Brazil (Southeast) | 40 mothers and their PTN (23–32 weeks gestation) 92 mothers and their FTN | TaqI BsmI ApaI FokI | The BsmI/TT and ApaI/AA genotype increased prematurity risk, regardless of vitamin D deficiency. Preterm newborns with FokI/GG genotypes had lower serum vitamin D concentrations. |