Safety of medication use during pregnancy in mainland China: based on a national health insurance database in 2015

Table 4 Factors associated with FDA category D/X medication use

Variables	Odds Ratio	95% CI	p value
Age	1.04	0.98–1.11	0.174
Area
Eastern	referent	referent	referent
Mid-western	2.54	0.99–6.21	0.045*
Insurance type
URBMI	referent	referent	referent
UEBMI	0.70	0.29–1.68	0.425
Deliver type
Natural delivery	referent	referent	referent
Others	1.00	0.44–2.14	0.998
Level of mostly visited hospital
Secondary hospital or below	referent	referent	referent
Tertiary hospital	2.10	0.94–4.91	0.076
Number of different medications used
< 4	referent	referent	referent
≥4	4.17	2.01–9.11	< 0.001 ***

FDA The U.S. Food and Drug Administration
URBMI Urban Resident Basic Medical Insurance
UEBMI Urban Employee Basic Medical Insurance
*p < 0.05, ***p < 0.001
The p value of mid-western area (0.045) and used four or more medications ( < 0.001) were deemed significant and thus set in boldface

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