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Table 2 prevalence and number of medications used by FDA risk category during pregnancy and each trimester

From: Safety of medication use during pregnancy in mainland China: based on a national health insurance database in 2015

 

Gestational stages

p valuea

Entire pregnancy

T1

T2

T3

Overall prevalence, %

5.4

4.5

6.0

0.001 **

11.1

Prevalence of each category among women with medication use, % b

 A

17.4

15.6

10.9

0.057

16.8

 B

61.9

37.7

34.2

< 0.001***

57.8

 C

38.7

68.9

72.8

< 0.001***

66.2

 D

3.2

2.9

3.1

0.973

5.0

 X

5.8

2.1

6.3

0.042 *

7.5

 Unknown

41.9

43.0

46.3

0.531

49.4

 Total number of different medications, n

171

227

318

 

321

Number of different medications in each category, n (%) c

 A

6 (3.5)

7 (3.1)

8 (2.5)

0.814

8 (2.5)

 B

40 (23.4)

54 (23.8)

71 (22.3)

0.916

67 (20.9)

 C

68 (39.8)

87 (38.3)

132 (41.5)

0.753

123 (38.3)

 D

6 (3.5)

8 (3.5)

12 (3.8)

0.984

19 (5.9)

 X

8 (4.7)

3 (1.3)

8 (2.5)

0.117

12 (3.7)

 Unknown

43 (25.2)

68 (30.0)

87 (27.4)

0.562

92 (28.7)

  1. aThe P value of comparison tests among three trimesters. * p < 0.05; ** p < 0.01; *** p < 0.001
  2. bEach pregnant woman could be exposed to more than one FDA category
  3. cColumns might not add to 100% because of rounding error