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Table 4 Antidiabetic drug use, by trimester, in livebirth pregnancies among women with pre-existing diabetes during 2001–2013 in the MSDD

From: Use of Antidiabetic drugs during pregnancy among U.S. women with Livebirth deliveries in the Mini-Sentinel system

 Use in the 90 Days Before PregnancyAny Use During PregnancyAny Use, First TrimesterAny Use, Second TrimesterAny Use, Third Trimester
Total unique pregnancies15,606 (100%)15,606 (100%)15,606 (100%)15,606 (100%)15,594 (100%)
Drug Product/Class
 Use of Any Drug13,847 (88.7%)14,488 (92.8%)13,322 (85.4%)12,876 (82.5%)12,998 (83.4%)
 Metformin6024 (38.6%)5886 (37.7%)5572 (35.7%)3533 (22.6%)2257 (14.5%)
 Sulfonylureas – Any Drug2018 (12.9%)2803 (18.0%)1916 (12.3%)1532 (9.8%)1414 (9.1%)
  Glipizide675 (4.3%)596 (3.8%)573 (3.7%)270 (1.7%)91 (0.6%)
  Glyburide976 (6.3%)2001 (12.8%)1097 (7.0%)1162 (7.5%)1268 (8.1%)
 Thiazolidinediones965 (6.2%)800 (5.1%)786 (5.0%)258 (1.7%)104 (0.7%)
 Combination Products565 (3.6%)502 (3.2%)480 (3.1%)166 (1.1%)73 (0.5%)
 Insulin7351 (47.1%)11,796 (75.6%)9625 (61.7%)10,776 (69.1%)11,328 (72.6%)