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Table 3 Factors associated with placenta accreta spectrum: results from univariate and logistic regression analyses

From: Risk factors for placenta accreta spectrum: findings from the Japan environment and Children’s study

Variable

Univariate analysis

Multivariate analysis

OR

95% CI

P value

aOR

95% CI

P value

Placenta previa

17.13

10.48–28.01

< 0.001

12.86

7.70–21.45

< 0.001

ART pregnancy

8.02

5.64–11.39

< 0.001

6.78

4.54–10.14

< 0.001

Maternal smoking status

 Never smoker

Ref

Ref

 Quit smoking during early pregnancy

0.74

0.46–1.17

0.193

0.83

0.51–1.35

0.452

 Smoking during pregnancy

1.83

1.11–3.01

0.017

1.95

1.15–3.31

0.013

Number of previous CSs

 0

Ref

Ref

 1

0.95

0.54–1.66

0.850

0.87

0.49–1.53

0.618

 ≥ 2

2.49

1.36–4.59

0.003

2.51

1.35–4.67

0.004

Uterine anomaly

5.31

1.69–16.70

0.004

3.97

1.24–12.68

0.020

Adenomyosis

3.05

0.76–12.35

0.118

1.77

0.41–7.52

0.442

Endometriosis

1.67

0.93–2.99

0.087

0.81

0.42–1.55

0.525

Uterine myoma

1.52

0.93–2.46

0.092

1.02

0.61–1.69

0.951

Maternal age

 ≤ 19 years

1.21

0.30–4.87

0.792

1.68

0.38–7.48

0.494

 20–24 years

Ref

Ref

 25–29 years

0.73

0.52–1.02

0.062

1.05

0.56–1.96

0.878

 30–34 years

0.86

0.64–1.16

0.333

1.06

0.58–1.95

0.848

 35–39 years

1.46

1.08–1.98

0.014

1.23

0.66–2.30

0.516

 ≥ 40 years

2.05

1.27–3.34

0.004

1.41

0.66–3.01

0.373

Number of IAs

 0

Ref

Ref

 1

1.17

0.78–1.76

0.442

1.30

0.85–1.97

0.224

 ≥ 2

1.32

0.72–2.43

0.369

1.29

0.68–2.45

0.433

  1. ART Assisted reproductive technology, IA Induced abortion, OR Odds ratio, CI Confidence interval, aOR Adjusted odds ratio, Ref Reference, CS Cesarean section