No association between early antiretroviral therapy during pregnancy and plasma levels of angiogenic factors: a cohort study

Table 2 Association between biomarkers and ART (type, duration and initiation time)

Biomarkers	Crude coefficient	CI (95%)	p-value	Adjusted coefficient^a	Adjusted CI (95%)	p-value
PlGF
PI-based ART^b	0.238	0.166–0.310	0.000	0.018^c	− 0.051 - 0.088	0.611
Other ART^b	0.201	0.095–0.307	0.000	0.028^c	− 0.064 - 0.121	0.552
ART exposure duration	0.020	0.014–0.026	0.000	0.001^d	− 0.006 - 0.007	0.873
PI exposure duration	0.018	0.011–0.025	0.000	0.000^d	−0.007 - 0.006	0.936
Time of ART initiation^e	−0.019	− 0.089 - 0.051	0.592	0.000^d	−0.066 - 0.066	0.997
sFlt1
PI-based ART^b	0.306	0.109–0.503	0.002	0.177^f	− 0.032 - 0.386	0.097
Other ART^b	0.233	−0.108 - 0.573	0.180	0.091^f	−0.246 - 0.428	0.597
ART exposure duration	0.003	−0.008 - 0.015	0.584	−0.001^g	−0.014 - 0.012	0.872
PI exposure duration	0.007	−0.004 - 0.019	0.218	0.002^g	−0.010 - 0.015	0.722
Time of ART initiation^e	0.085	−0.074 - 0.244	0.294	0.024 ^h	−0.139 - 0.188	0.772
sFlt1/PlGF Ratio
PI-based ART^b	0.033	−0.179 - 0.245	0.759	0.145ⁱ	−0.076 - 0.366	0.199
Other ART^b	−0.036	−0.386 - 0.314	0.840	0.063ⁱ	−0.319 - 0.445	0.747
ART exposure duration	−0.014	−0.028 - 0.000	0.044	0.000^f	−0.018 - 0.017	0.956
PI exposure duration	−0.007	−0.021 - 0.006	0.299	0.003^h	−0.013 - 0.019	0.683
Time of ART initiation^e	0.104	−0.071 - 0.279	0.243	0.028^h	−0.152 - 0.208	0.761

ART Antiretroviral therapy, PI Protease inhibitor, CI Confidence interval
^a Linear Generalized Estimating Equations
^b Control: no ART
^c Adjusted for gestational age at the date of test and ethnicity
^d Adjusted for gestational age at the date of test, body mass index and ethnicity
^e Control: ART initiated during pregnancy
^f Adjusted for gestational age at the date of test and body mass index
^g Adjusted for gestational age at the date of test and maternal age
^h Adjusted for gestational age at the date of test, maternal age and ethnicity
ⁱ Adjusted for gestational age at the date of test, maternal age, body mass index, parity, and sex of the fetus

ISSN: 1471-2393