Table 3 Comparison of baseline characteristics and maternal outcomes of controlled and uncontrolled hypothyroid patients before conception
CLINICAL CHARACTERISTICS | TSH PRECONCEPTION | P -value | |
|---|---|---|---|
|  | Controlled (up to 2.5 mIU/L) N = 170 | Uncontrolled (greater than 2.5 mIU/L) N = 207 | |
| Â | N (%) | N (%) | |
Age (years) | |||
 18–25 | 15 (3.98) | 16 (4.24) | 0.43a |
 26–33 | 104 (27.59) | 117 (31.03) | |
 34–40 | 50 (13.26) | 69 (18.30) | |
 41–47 | 1 (0.27) | 5 (1.33) | |
Parity | |||
 Nulliparous | 42 (11.29) | 54 (14.52) | 0.8 |
 Multiparous | 125 (33.60) | 151 (40.59) | |
Body Mass Index (Kg/m2) | |||
 Underweight (< 18.5) | 7 (2.06) | 6 (1.77) | 0.2 |
 Normal (18.5–24.9) | 45 (13.27) | 54 (15.93) | |
 Overweight (25–29.9) | 56 (16.52) | 60 (17.70) | |
 Obesity class I (30–34.9) | 31 (9.14) | 57 (16.81) | |
 Obesity class II and above (> = 35) | 13 (3.83) | 10 (2.95) | |
Etiology of Hypothyroidism | |||
 Autoimmune | 163 (43.35) | 199 (52.93) | 0.7 |
 Post treatment$ | 7 (1.86) | 7 (1.86) | |
Thyroid antibodies | |||
 Positive | 54 (36.99) | 60 (41.10) | 0.7 |
 Negative | 14 (9.59) | 18 (12.33) | |
COMORBIDITIES | |||
 Diabetes Mellitus | |||
  Yes | 10 (2.65) | 18 (4.77) | 0.3 |
  No | 160 (42.44) | 189 (50.13) | |
 Gestational diabetes mellitus | |||
  Yes | 38 (10.08) | 44 (11.67) |  |
  No | 132 (35.01) | 163 (43.24) | 0.8 |
 Hypertension | |||
  Normotensive | 151 (40.05) | 176 (46.68) |  |
  Previous Gestational Hypertension/Chronic Hypertension | 19 (5.04) | 31 (8.22) | 0.3 |
MATERNAL OUTCOMES | |||
 Mode of labor (for live births only) | |||
  Spontaneous | 29 (14.50) | 37 (18.50) | 0.24 |
  Induced | 45 (22.50) |  | |
  Augmented | 27 (13.50) | 44 (22.00) | |
  Not applicable due to Caesarean section |  | 18 (9.00) | |
 Mode of delivery (for live births only) | |||
  LSCS | 80 (23.19) | 124 (35.94) | 0.012 |
  Instrumental | 7 (2.03) | 6 (1.74) | |
  SVD | 71 (20.58) | 57 (16.52) | |
 Pregnancy outcomes | |||
  Abortion | 12 (3.18) | 15 (3.98) | 0.9a |
  Live Birth (Twins/Triplets) | 157 (41.64) | 187 (49.60) | |
  Ectopic | 0 (0.00) | 1 (0.27) | |
  Termination of Pregnancy | 0 (0.00) | 1 (0.27) | |
  Intrauterine Death/Stillbirth | 1 (0.27) | 3 (0.80) | |
 Gestational Hypertension | |||
  Yes | 13 (7.6) | 21 (10.1) | 0.4 |
  No | 157 (92.4) | 186 (89.9) | |
 Pre-Eclampsia | |||
  Yes | 2 (1.2) | 8 (3.9) | 0.19a |
  No | 168 (98.8) | 199 (96.1) | |
 Postpartum Hemorrhage | |||
  Yes | 56 (32.9) | 95 (45.9) | 0.01 |
  No | 114 (67.1) | 112 (54.1) | |