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Table 3 Gene expression in placental tissue from healthy controls, women with untreated depression and women on antidepressant treatment

From: The effect of antenatal depression and antidepressant treatment on placental tissue: a protein-validated gene expression study

 

Healthy controls

(n 47)

Women with untreated depression

(n 25)

Women on antidepressant treatment

(n 45)

  

Gene

n

Median (IQR)

n

Median (IQR)

n

Median (IQR)

p

p bonferroni

NPY2R

40

12.3 (10.1–13.3)

20

9.7 (9.1–11.7)

37

10.9 (9.3–12.6)

0.024

0.960

NGF

47

8.8 (8.1–9.5)

25

8.4 (8.3–8.9)

45

8.3 (7.8–9.0)

0.049

1.984

HTR1A

34

10.8 (9.6–12.3)

21

9.0 (7.7–11.3)

27

10.4 (8.8–11.7)

0.049

1.988

OXTR

47

9.5 (8.4–11.1)

25

9.3 (7.4–10.0)

45

8.9 (7.9–10.3)

0.081

 

BDNF

47

6.3 (5.9–6.8)

25

6.0 (5.2–6.4)

45

6.4 (5.8–6.7)

0.091

 

CRH

47

0.7 (−0.2–2.3)

24

0.1 (−1.0–1.1)

45

1.0 (− 0.1–2.1)

0.102

 

NR3C1

47

3.0 (2.6–3.4)

25

2.8 (2.0–3.0)

45

2.8 (2.3–3.2)

0.133

 

MAOA

47

1.0 (0.7–1.6)

25

0.7 (0.3–1.1)

45

1.1 (0.6–1.5)

0.153

 

TPH1

46

11.7 (10.7–12.7)

24

12.2 (11.3–12.7)

44

11.6 (10.8–12.3)

0.189

 

RAF-1

47

5.1 (4.7–5.4)

25

4.8 (4.5–5.2)

45

5.0 (4.7–5.3)

0.193

 

HTR3E

47

9.9 (8.9–10.8)

24

9.1 (8.7–10.4)

45

9.9 (8.7–10.8)

0.195

 

ROCK2

47

3.0 (2.7–3.3)

25

2.9 (2.5–3.1)

44

2.9 (2.5–3.3)

0.204

 

AADC

33

11.4 (10.0–12.3)

19

11.5 (8.8–13.9)

30

10.8 (8.8–11.9)

0.206

 

OXT

32

12.9 (11.4–14.0)

18

12.4 (11.1–12.7)

25

12.6 (11.5–13.2)

0.280

 

SRD5A1

47

9.2 (8.8–9.6)

25

9.0 (8.6–9.4)

45

9.2 (8.7–9.6)

0.301

 

ROCK1

46

4.1 (3.8–4.4)

25

3.8 (3.7–4.2)

45

3.8 (3.5–4.1)

0.313

 

COMT

45

2.9 (2.2–3.2)

25

3.1 (2.8–3.3)

43

2.9 (2.5–3.4)

0.318

 

TPH2

46

10.4 (9.3–12.2)

25

11.1 (10.4–11.7)

44

11.3 (10.2–12.1)

0.356

 

HSD11B1

47

5.6 (4.8–6.4)

25

5.8 (4.2–6.3)

45

5.9 (5.2–6.4)

0.426

 

CYP3A4

26

12.0 (9.5–13.5)

14

11.3 (9.9–12.7)

19

11.1 (8.6–12.5)

0.456

 

CYP2D6

47

8.7 (7.9–9.7)

25

8.7 (7.6–9.1)

45

8.8 (8.0–9.4)

0.478

 

GABRG2

43

9.9 (8.9–10.7)

23

10.3 (9.0–11.8)

42

9.7 (8.7–11.3)

0.478

 

CYP1A2

25

11.7 (10.7–14.1)

19

10.9 (9.8–12.1)

29

11.4 (9.6–13.1)

0.506

 

PTGDS

47

2.0 (1.5–2.7)

25

1.9 (1.1–2.6)

45

1.9 (1.0–2.6)

0.539

 

HSD11B2

47

2.5 (1.7–3.3)

24

1.9 (1.6–2.6)

45

2.0 (1.4–3.1)

0.573

 

SLC6A2

47

3.6 (3.1–4.4)

25

3.5 (3.1–4.2)

45

3.7 (3.5–4.3)

0.624

 

SLC6A4

46

3.7 (3.3–4.1)

24

3.8 (3.5–4.1)

45

3.8 (3.4–4.4)

0.669

 

CDH2

47

10.1 (8.3–11.8)

25

10.0 (8.8–11.8)

44

9.4 (8.5–11.0)

0.685

 

NTRK1

37

10.1 (7.5–11.8)

18

9.0 (7.3–11.4)

31

9.5 (8.0–10.7)

0.724

 

ALAD

47

4.6 (4.4–4.9)

25

4.6 (4.3–4.9)

45

4.6 (4.3–5.0)

0.726

 

NPY1R

47

9.6 (9.0–10.0)

25

9.6 (8.7–10.0)

45

9.6 (8.5–10.5)

0.769

 

CREB1

47

4.2 (3.7–4.4)

25

3.9 (3.7–4.4)

45

4.0 (3.7–4.4)

0.824

 

CRHBP

47

6.5 (5.4–7.6)

25

6.4 (5.3–8.0)

45

6.7 (5.5–8.1)

0.851

 

ABCB1

47

5.3 (4.1–5.8)

25

4.8 (4.1–5.9)

45

5.1 (4.1–6.7)

0.855

 

VEGFA

47

4.6 (3.6–5.4)

25

4.5 (3.6–5.4)

45

4.4 (3.6–5.0)

0.860

 

HTR7

46

10.1 (9.1–11.6)

25

10.2 (9.2–10.9)

45

10.1 (8.9–10.8)

0.879

 

PGF

47

0.1 (−1.0–0.7)

25

−0.1 (−1.0–0.9)

45

−0.1 (− 0.6–0.3)

0.893

 

CCK

46

10.4 (8.4–11.3)

24

10.2 (8.2–11.3)

45

9.4 (8.1–11.4)

0.923

 

NTRK2

47

9.2 (8.2–9.9)

24

9.1 (8.6–9.9)

44

9.0 (8.4–9.8)

0.956

 

VIP

46

10.1 (9.2–10.9)

25

9.8 (9.4–10.5)

45

9.9 (9.4–10.6)

0.971

 
  1. Data presented as median ΔCt (IQR). Statistical tests by one-way ANOVA or Kruskal Wallis test, depending on normal distribution. Genes sorted according to the degree of statistical significance