| Healthy controls (n 47) | Women with untreated depression (n 25) | Women on antidepressant treatment (n 45) |  |  | |||
---|---|---|---|---|---|---|---|---|
Gene | n | Median (IQR) | n | Median (IQR) | n | Median (IQR) | p | p bonferroni |
NPY2R | 40 | 12.3 (10.1–13.3) | 20 | 9.7 (9.1–11.7) | 37 | 10.9 (9.3–12.6) | 0.024 | 0.960 |
NGF | 47 | 8.8 (8.1–9.5) | 25 | 8.4 (8.3–8.9) | 45 | 8.3 (7.8–9.0) | 0.049 | 1.984 |
HTR1A | 34 | 10.8 (9.6–12.3) | 21 | 9.0 (7.7–11.3) | 27 | 10.4 (8.8–11.7) | 0.049 | 1.988 |
OXTR | 47 | 9.5 (8.4–11.1) | 25 | 9.3 (7.4–10.0) | 45 | 8.9 (7.9–10.3) | 0.081 |  |
BDNF | 47 | 6.3 (5.9–6.8) | 25 | 6.0 (5.2–6.4) | 45 | 6.4 (5.8–6.7) | 0.091 |  |
CRH | 47 | 0.7 (−0.2–2.3) | 24 | 0.1 (−1.0–1.1) | 45 | 1.0 (− 0.1–2.1) | 0.102 |  |
NR3C1 | 47 | 3.0 (2.6–3.4) | 25 | 2.8 (2.0–3.0) | 45 | 2.8 (2.3–3.2) | 0.133 |  |
MAOA | 47 | 1.0 (0.7–1.6) | 25 | 0.7 (0.3–1.1) | 45 | 1.1 (0.6–1.5) | 0.153 |  |
TPH1 | 46 | 11.7 (10.7–12.7) | 24 | 12.2 (11.3–12.7) | 44 | 11.6 (10.8–12.3) | 0.189 |  |
RAF-1 | 47 | 5.1 (4.7–5.4) | 25 | 4.8 (4.5–5.2) | 45 | 5.0 (4.7–5.3) | 0.193 |  |
HTR3E | 47 | 9.9 (8.9–10.8) | 24 | 9.1 (8.7–10.4) | 45 | 9.9 (8.7–10.8) | 0.195 |  |
ROCK2 | 47 | 3.0 (2.7–3.3) | 25 | 2.9 (2.5–3.1) | 44 | 2.9 (2.5–3.3) | 0.204 |  |
AADC | 33 | 11.4 (10.0–12.3) | 19 | 11.5 (8.8–13.9) | 30 | 10.8 (8.8–11.9) | 0.206 |  |
OXT | 32 | 12.9 (11.4–14.0) | 18 | 12.4 (11.1–12.7) | 25 | 12.6 (11.5–13.2) | 0.280 |  |
SRD5A1 | 47 | 9.2 (8.8–9.6) | 25 | 9.0 (8.6–9.4) | 45 | 9.2 (8.7–9.6) | 0.301 |  |
ROCK1 | 46 | 4.1 (3.8–4.4) | 25 | 3.8 (3.7–4.2) | 45 | 3.8 (3.5–4.1) | 0.313 |  |
COMT | 45 | 2.9 (2.2–3.2) | 25 | 3.1 (2.8–3.3) | 43 | 2.9 (2.5–3.4) | 0.318 |  |
TPH2 | 46 | 10.4 (9.3–12.2) | 25 | 11.1 (10.4–11.7) | 44 | 11.3 (10.2–12.1) | 0.356 |  |
HSD11B1 | 47 | 5.6 (4.8–6.4) | 25 | 5.8 (4.2–6.3) | 45 | 5.9 (5.2–6.4) | 0.426 |  |
CYP3A4 | 26 | 12.0 (9.5–13.5) | 14 | 11.3 (9.9–12.7) | 19 | 11.1 (8.6–12.5) | 0.456 |  |
CYP2D6 | 47 | 8.7 (7.9–9.7) | 25 | 8.7 (7.6–9.1) | 45 | 8.8 (8.0–9.4) | 0.478 |  |
GABRG2 | 43 | 9.9 (8.9–10.7) | 23 | 10.3 (9.0–11.8) | 42 | 9.7 (8.7–11.3) | 0.478 |  |
CYP1A2 | 25 | 11.7 (10.7–14.1) | 19 | 10.9 (9.8–12.1) | 29 | 11.4 (9.6–13.1) | 0.506 |  |
PTGDS | 47 | 2.0 (1.5–2.7) | 25 | 1.9 (1.1–2.6) | 45 | 1.9 (1.0–2.6) | 0.539 |  |
HSD11B2 | 47 | 2.5 (1.7–3.3) | 24 | 1.9 (1.6–2.6) | 45 | 2.0 (1.4–3.1) | 0.573 |  |
SLC6A2 | 47 | 3.6 (3.1–4.4) | 25 | 3.5 (3.1–4.2) | 45 | 3.7 (3.5–4.3) | 0.624 |  |
SLC6A4 | 46 | 3.7 (3.3–4.1) | 24 | 3.8 (3.5–4.1) | 45 | 3.8 (3.4–4.4) | 0.669 |  |
CDH2 | 47 | 10.1 (8.3–11.8) | 25 | 10.0 (8.8–11.8) | 44 | 9.4 (8.5–11.0) | 0.685 |  |
NTRK1 | 37 | 10.1 (7.5–11.8) | 18 | 9.0 (7.3–11.4) | 31 | 9.5 (8.0–10.7) | 0.724 |  |
ALAD | 47 | 4.6 (4.4–4.9) | 25 | 4.6 (4.3–4.9) | 45 | 4.6 (4.3–5.0) | 0.726 |  |
NPY1R | 47 | 9.6 (9.0–10.0) | 25 | 9.6 (8.7–10.0) | 45 | 9.6 (8.5–10.5) | 0.769 |  |
CREB1 | 47 | 4.2 (3.7–4.4) | 25 | 3.9 (3.7–4.4) | 45 | 4.0 (3.7–4.4) | 0.824 |  |
CRHBP | 47 | 6.5 (5.4–7.6) | 25 | 6.4 (5.3–8.0) | 45 | 6.7 (5.5–8.1) | 0.851 |  |
ABCB1 | 47 | 5.3 (4.1–5.8) | 25 | 4.8 (4.1–5.9) | 45 | 5.1 (4.1–6.7) | 0.855 |  |
VEGFA | 47 | 4.6 (3.6–5.4) | 25 | 4.5 (3.6–5.4) | 45 | 4.4 (3.6–5.0) | 0.860 |  |
HTR7 | 46 | 10.1 (9.1–11.6) | 25 | 10.2 (9.2–10.9) | 45 | 10.1 (8.9–10.8) | 0.879 |  |
PGF | 47 | 0.1 (−1.0–0.7) | 25 | −0.1 (−1.0–0.9) | 45 | −0.1 (− 0.6–0.3) | 0.893 |  |
CCK | 46 | 10.4 (8.4–11.3) | 24 | 10.2 (8.2–11.3) | 45 | 9.4 (8.1–11.4) | 0.923 |  |
NTRK2 | 47 | 9.2 (8.2–9.9) | 24 | 9.1 (8.6–9.9) | 44 | 9.0 (8.4–9.8) | 0.956 |  |
VIP | 46 | 10.1 (9.2–10.9) | 25 | 9.8 (9.4–10.5) | 45 | 9.9 (9.4–10.6) | 0.971 |  |