Effects and outcomes of septostomy in twin-to-twin transfusion syndrome after fetoscopic laser therapy

Table 1 Characteristics of the patients with twin-to-twin transfusion syndrome patients with and without septostomy after laser therapy

	With post laser septostomy (N = 12)	Without post laser septostomy (N = 147)	P value
Maternal age at operation (year-old)	29.6 (24.9, 42.2)	31.3 (23.4, 43.4)	0.43^a
Gestational age at operation (weeks)	21.1 (18, 25)	20.7 (16, 26)	0.19^a
Gestational age at delivery (week)	27.8 (19.9, 37.3)	34.4 (20.3, 40.0)	0.011^a
PROMs within 3 weeks after operation ((%)number)	33.3% (4/12)	5.4% (8/147)	0.004^c
Interval from operation to delivery (days)	24 (8115)	88 (1, 159)	0.002^a
Cord entanglement ((%)number)	16.7% (2/12)	0% (0/147)	0.005^c
Amniotic band syndrome	0% (0/12)	1.4% (2/147)	1.0^c
Severe brain image anomaly	7.6% (1/13)	1.4% (3/218)	0.21^c
Mild brain image anomaly	15.4% (2/13)	4.1% (8/218)	0.10^c
Total brain image anomaly	23.0% (3/13)	5.0% (11/218)	0.035^c
Dual fetal survival ((%)number)	41.7% (5/12)	59.2% (87/147)	0.24^b
At least one fetal survival((%)number)	75.0% (8/12)	89.1% (131/147)	0.047^c
Total fetal survival ((%)number)	54.2% (13/24)	73.6% (218/296)	0.041^b

Data are expressed as median (min, max) and percentage (frequencies)
Mild cerebral image anomaly: defined by lesions detected in cranial ultrasound scans with the presence of at least one of the following: intraventricular hemorrhage (IVH) grade I and II, lenticulostriate vasculopathy, and subependymal pseudocysts
Severe cerebral image anomaly: defined by the presentation of one of the following signs: IVH grade III or grade IV, cystic periventricular leukomalacia grade II or more, porencephalic cysts, and ventricular dilatation. Wentricular dilatation was diagnosed when the width of the unilateral or of both lateral ventricles exceeded the 97th percentile
PROMs Premature rupture of membranes
^aMann–Whitney U test
^bchi-squared test
^cFisher’s exact test

ISSN: 1471-2393