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Table 1 List of included regions and methods for diagnosing GDM

From: Changing diagnostic criteria for gestational diabetes in Sweden - a stepped wedge national cluster randomised controlled trial - the CDC4G study protocol

Centres Number of births 2017a Indication for a diagnostic OGTT Diagnostic criteria prior to switch (mmol/L) Method for glucose analysis
Previous BMI at booking FHd Polyhyd ramnios Accelerated fetal growth RPG
GDM Macro somiab LGAc Stillbirth
1. Stockholm 28,602 T1 & 24–28 24–28    ≥35   Yes Yes RPGe ≥ 9 mmol/L at booking, week 25, 29, 32/33, 37/38. FPG < 7.0 and
2-h PG 8.9–11.1
Roche Cobas
Beckman Coulter Au.
Siemens Advia
(hexokinase)
2. Örebro 3565 24–28 24–28    ≥35 24–28 Yes Yes-within 3 days RPGe ≥ 9 mmol/L at booking, week 24, 28/29, 33, 37. FPG < 7.0 and
2-h PG 8.9–11.0
Siemens Advia
(hexokinase)
3. Västmanland 3120 24–28 24–28    > 35   Yes Yes RPGe ≥ 9.0 mmol/L at booking week 25, 30, 35. FPG < 7.0 and
2-h PG 8.9–11.
Beckman Coulter Au
(hexokinase)
4. Dalarna 3232 12–14/24–28 24–28 24–28   > 35 24–28 Yes Yes RPGe ≥ 9.0 mmol/L at booking, week 24, 28/29, 33, 37. FPG < 7.0 and/or
2-h PG 8.9–11.1
Siemens Advia (hexokinase)
5. Uppsala 4200 12–14/24–28 24–28 24–28   ≥35 24–28 Yes Yes RPGe ≥ 8.8 mmol/L at booking, week 25, 28/29, 33, 37 FPG ≥7.0 and/or 2-h PG ≥10.0 Abbott Architect (hexokinase)
6. Göteborg 9550 25–29 25–29 25–29   ≥35 25–29 Yes (Yes) Within 1 week if RPGe 8.0–12.1 mmol/L at first antenatal care visit, week 25, 28–29, 35–36. FPG ≥7.0 and/or 2-h PG ≥10.0
RPGc ≥ 12.2
Nova Biomedical StatStrip TM Multi-Well™ (glucose oxidase)
7. Gotland 538 24–28 24–28   24–28 ≥35 24–28 Yes Yes RPGe ≥ 9.0 mmol/L at enrollment week 25, 29, 32/33, 37/38. FPG < 7.0 and 2-h PG 8.9–11.0 HemoCue AB HemoCue 201 RT (glucose dehydrogenase)
8. Halland 4446 12/ 24–28   24–28 24–28 ≥30 24–28 Yes Yes RPGe ≥ 8.0 mmol/L at enrollment, week 12, 28/29, 32, 37 FPG < 7.0 and 2-h PG 9.0–11.1 HemoCue AB
HemoCue 201 RT (glucose dehydrogenase)
9. Malmö 4944 10–12 10–12    ≥35 10–12 Yes No Capillary 75 g OGTT week 28 in all women.
FPGe ≥ 7 and/or 2-h PGe ≥ 10.0 mmol/L indication for a diagnostic OGTT
FPG ≥7.0 and/or
2-h PG ≥9.0
Roche Cobas (hexokinase)
10. Lund 3703 10–12 10–12    ≥35 10–12 Yes No
11. Kristianstad 2085 10–12 10–12    ≥35 10–12 Yes No
  1. Legend: When not otherwise stated, glucose measurement is based on venous plasma
  2. BMI body mass index, FH family history, FPG fasting plasma glucose, IUFD intrauterine fetal death, LGA large for gestational age, OGTT oral glucose tolerance test, PG plasma glucose, RPG random plasma glucose, T1 trimester 1
  3. aNumber of births per year based on data from the Swedish Medical Birth register year 2017
  4. bDefined as birth weight ≥ 4.5 kg
  5. cDefined as birth weight ≥ + 2 standard deviations above the Swedish reference curve [31]
  6. dIn Dalarna, Malmö, Lund, Kristianstad, Uppsala, Gotland, Halland defined as first degree relative with type 1 or type 2 diabetes, otherwise first degree relative with type 2 diabetes
  7. eBased on capillary samples