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Table 3 Associations of maternal social supports and stressful life events with VSD in offspring

From: Associations between maternal social support and stressful life event with ventricular septal defect in offspring: a case-control study

 

Before Propensity Score Matching

After Propensity Score Matching

Controls

n = 262

Cases

n = 202

Crude Model

OR (95% CI)

Adjust Model

aOR (95% CI)

Controls

n = 168

Cases

n = 202

OR (95% CI)

Social support index

 0–4 (Low)

68

76

1

1

45

76

1

 5–7 (Medium high)

95

67

0.631 (0.401, 0.992) *

0.523 (0.283, 0.967) *

64

67

0.620 (0.375, 1.025)

 8 (High)

99

56

0.533 (0.337, 0.844) **

0.510 (0.321, 0.854) *

59

56

0.592 (0.353, 0.992) *

Stressful life event index

 0 (Low)

167

111

1

1

106

111

1

 1 (Medium high)

60

48

1.204 (0.768, 1.886)

1.190 (0.643, 2.201)

40

48

1.146 (0.697, 1.884)

  ≥ 2 (High)

26

39

2.257 (1.300, 3.916) **

2.342 (1.138, 4.819) *

16

39

2.328 (1.228, 4.414) **

Stressful Life event with social supporta

 Low stress & High support

178

108

1

 

113

108

1

 Low stress & Low support

49

51

1.715 (1.084, 2.715) *

2.059 (1.104, 3.841) *

33

51

1.617 (0.970, 2.696)

 High stress & High support

13

17

2.155 (1.007, 4.612) *

2.699 (1.042, 6.988) *

8

17

2.223 (0.922, 5.364)

 High stress & Low support

13

22

2.789 (1.349, 5.765) *

2.781 (1.033, 7.489) *

8

22

2.877 (1.228, 6.739) *

  1. Adjusted Model: adjusted for maternal ethic, maternal age at delivery, maternal education, marital status, residence, maternal prepregnancy obesity, multiple births, infant gender, and family history of CHD, maternal smoking/drinking, maternal diabetes/hypertension, maternal folic acid supplementation
  2. aOR adjusted odds ratio CI confidence interval OR odds ratio VSD Ventricular septal defect
  3. a Women were designated as having low event if the life events index score was 0–1 and as having high event if it was ≥2. Women were designated as having low social support if the social support index was 0–4 and as having high support if it was ≥5
  4. * p value < 0.05; ** p value < 0.01