From: Endometrial carcinoma in a gravid uterus: a case report and literature review
First author | Year (Reference number) | Age (years) | Timing of diagnosis | Outocome | Period after diagnosis | Symptoms | The results of histopathogical examination | Immunohisotocheical staining | Stage | Surgical treatment | |
---|---|---|---|---|---|---|---|---|---|---|---|
Kovács AG | 1996 [5] | 35 | Abortion | NA | NED | 1 year | Abnormal genital bleeding | EA grade 1–2 | NA | IA | Brachytherapy + TAH + BSO + RT |
The authors hypothesized that pregnancy may adversely affect the tumor growth; however, it cannot be proven because of the limited number of cases. | |||||||||||
Kodama J | 1997 [6] | 30 | Postpartum | 7 months | DOD | 8 months | Abnormal genital bleeding | Poorly differentiated adenosquamous carcinoma | NA | IIIC | C |
The authors opined that an immature, progesterone-unresponsive endometrium could be the possible mechanism of allowing endometrial carcinoma to develop in pregnancy. | |||||||||||
Schammel DP | 1998 [7] | 38 | Abortion | 9 weeks | NED | 58 months | Infertility | EA grade 1 | NA | IA | Repeat curettage with progesterone therapy |
41 | Abortion | 13 weeks | NED | 48 months | Abnormal genital bleeding | EA grade 1 | NA | IA | TAH + BSO | ||
29 | Abortion | 9–10 weeks | NA | NA | None | EA grade 1 | NA | IA | NA | ||
34 | Abortion | 13 weeks | NED | 12 months | Abnormal genital bleeding | EA grade 1 | NA | IA | TAH + BSO | ||
33 | Postpartum | During cesarean delivery | NED | 57 months | None | EA grade 1 | NA | IA | Repeat curettage with progesterone therapy | ||
The authors considered that the fate of the more advanced-stage tumors with deeper myometrial invasion or high-grade cytologic features may be less subject to the protective effects of gestational progesterone. | |||||||||||
Ayhan A | 1999 [8] | 44 | Abortion | 5 weeks | NA | NA | Abnormal genital bleeding | EA grade 1 | NA | IA | TAH + BSO + LND + OM |
The authors cited a previous report which observed that hCG inhibits the DMBA-induced breast carcinogenesis in rats through an insulin-like growth factor-dependent mechanism. | |||||||||||
Foersterling DL | 1999 [9] | 31 | Postpartum | 9 weeks | NED | 1 year | Abnormal genital bleeding | EA grade 1 | NA | IA | TAH + BSO |
The authors opined that in pregnancy-associated endometrial carcinoma, part of the lining undergoes gestational change, whereas another part becomes neoplastic. The portion of the endometrium which becomes neoplastic may be sensitive to estrogen, yet unresponsive to progesterone. | |||||||||||
Vaccarello L | 1999 [10] | 35 | Abortion | 9 weeks | NED | 31 months | Abnormal genital bleeding | EA grade 1 | NA | IA | TAH + BSO |
40 | Postpartum | 4 months | NED | 6 years | Abnormal genital bleeding | EA grade 1 | NA | IA | TAH + BSO | ||
32 | Postpartum | 4 months | NED | 3.5 years | Abnormal genital bleeding | EA grade 2 | NA | NA | TAH + BSO | ||
They concluded that with concomitant secretory endometrium, the malignant regions must be progesterone refractory. | |||||||||||
Mitsushita J | 2000 [11] | 28 | Postpartum | 6 months | NA | NA | Previous history of endometrioid carcinoma | EA grade 1 | ER: positive PR: positive | IA | TAH |
The authors did not discuss the association between pregnancy and endometrioid carcinoma. | |||||||||||
Ishioka S | 2000 [12] | 25 | Postpartum | 14 months | NED | 6 months | Abnormal genital bleeding | EA grade 1 | ER: positive PR: negative p53: negative | IA | mRH + BSO + LND |
The authors concluded that the occurrence of postpartum EC was extremely rare probably due to the anti-tumor effects of progesterone. | |||||||||||
Ichikawa Y | 2001 [13] | 35 | Postpartum | 6 months | NED | 3.5 years | Lower abdominal pain | EA grade 1 | NA | IB | TAH + BSO + LND + OM + Appendectomy |
The authors speculated that high progesterone levels during pregnancy may protect against EC. | |||||||||||
Itoh K | 2004 [14] | 39 | Postpartum | 6 months | NED | 3 years | Abnormal genital bleeding | EA grade 1 | ER: negative PR: negative | IB | TAH + BSO + LND |
The authors concluded that the anticancer effect of progesterone during pregnancy was in effect in these tumors. | |||||||||||
Hannuna KY | 2009 [3] | 34 | Abortion | 12 weeks | NED | 18 months | Abortion | EA grade 1–2 | ER: positive PR: positive CK7: positive CK20: negative β-hCG: negative E-cadherin: positive EpCAM: positive Placental alkaline phosphatase: positive | IA | D&C |
The authors speculated that the presence of EC might have been related to a hypoxic damage of the chorionic villi. It might suggest a causal correlation between endometrial malignancy and spontaneous abortion. | |||||||||||
The authors found that most case reports of first trimester EA are also reported as arising in a focal lesion. | |||||||||||
Terada T | 2009 [15] | 29 | Concurrent endometrial adenocarcinoma and an early pregnancy loss | NA | NA | Abortion | EA grade 2 | ER: positive PR: positive p53: positive vimentin: positive CA19–9: focal positive CA125: positive Ki-67: 80% labelling CEA: negative PTEN: negative p16: negative | NA | Repeat curettage without progesterone therapy | |
The authors considered that EC associated with pregnancy were mostly in stages IA, and were histologically EAs. | |||||||||||
Akil A | 2012 [16] | 45 | Concurrent endometrial adenocarcinoma and an early pregnancy loss | NA | NA | Abortion | EA grade 1 | NA | IA | TAH + BSO + LND | |
The authors concluded that the routine histological examination of the curettage specimens for all first trimester abortions, independent of the age of the patient, should be encouraged. | |||||||||||
Saciragic L | 2014 [17] | 36 | Abortion | 8 weeks | NA | NA | Abnormal genital bleeding | EA grade 1 | Ki67: positive | IA | TAH + BSO + LND |
The authors discussed that in a woman with progesterone-resistant endometrium, development of endometrial carcinoma could be potentiated by the relatively hyperestrogenic environment of early pregnancy and subsequently allowed to proliferate further due to a lack of response to progesterone. | |||||||||||
Bayoglu Tekin Y | 2014 [18] | 36 | Abortion or ectopic pregnancy | NA | NED | 1 year | Ectopic pregnancy | EA grade 1 | NA | NA | Curettage with progesterone therapy |
The authors though that the presence of EC might have been related to the damage of the chorionic villi, suggesting a causal correlation between EC and spontaneous abortions. | |||||||||||
Zhou F | 2015 [19] | 40 | Concurrent endometrial adenocarcinoma and an early pregnancy loss | NA | NA | Abortion | EA grade 1 | ER: positive PR: positive p53: negative | NA | Repeat curettage without progesterone therapy | |
33 | Concurrent endometrial adenocarcinoma and an early pregnancy loss | NA | NA | Abortion | EA grade 1 | ER: positive PR: positive p53: negative | NA | Repeat curettage without progesterone therapy | |||
The authors considered that the careful histological examination of the curettage specimens for all first trimester pregnancy losses should be encouraged. | |||||||||||
Rizzuto I | 2019 [20] | 29 | Pregnancy of 7 weeks gestation | NA | NED | 8 years | Abnormal genital bleeding | EA | NA | NA | Serial endometrial biopsy with insertion of a Levonorgestrel intrauterine device |
Conservative management for EC in young women is possible including a case with an incidental diagnosis in pregnancy. | |||||||||||
Our case | 2019 | 35 | Placenta accreta spectrum | Cesarean hysterectomy | NED | 4 years | None | EA grade 1 | ER: positive PR: positive p53: negative | IA | Cesarean hysterectomy Laparoscopic BSO + LND |