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Table 2 Baseline and Follow-up data for evaluation and monitoring of women enrolled in the OTTILIA and FIRST registries

From: Rationale and design of two prospective, multicenter, observational studies on reproductive outcome in women with recurrent failures after spontaneous or assisted conception: OTTILIA and FIRST registries

OTTILIA

Baseline

Clinical information:

 • Maternal age

 • Body Mass Index

 • Smoking habit

 • Reproductive history (previous pregnancies and obstetric complications occurred)

 • Personal and family history of VTE

 • Presence of inherited or acquired thrombophilias

 • Thrombophilic risk factors

Index-pregnancy information:

 • Results of performed imaging tests, (ultrasonography, Doppler ultrasonography)

 • Invasive prenatal testing (i.e. villous sampling, amniocentesis)

 • Antithrombotic prophylaxis (brand, doses/day, duration)

Follow-up

Pregnancy outcomes:

• Live birth (gestational age, delivery mode, sex, birth weight, fetal or maternal hemorrhage)

• Obstetric complications (PL, IUFD, gestational hypertension, preeclampsia, HELLP syndrome, SGA newborns, placental abruption)

• VTE

FIRST

Baseline

Clinical information:

 • Maternal age

 • Body Mass Index

 • Smoking habit

 • Reproductive history (previous spontaneous pregnancies, ART attempts)

 • Cause of infertility (female, male, mixed or idiophatic),

 • Personal and family history of VTE

 • Presence of inherited or acquired thrombophilias

 • Thrombophilic risk factors

Index-ART cycle information:

 • Fertilization (autologous/heterologous)

 • Type of ART procedure (IUI, IVF, ICSI, Other)

 • Ovarian stimulation (brand, doses/day, duration)

 • Antithrombotic prophylaxis (brand, doses/day, duration),

 • Number of oocytes retrieved

 •Number of embryo transfers

Follow-up

ART outcomes:

• Clinical pregnancy

• Live birth (gestational age, delivery mode, sex, birth weight, fetal or maternal hemorrhage)

• Obstetric complications (PL, IUFD, gestational hypertension, preeclampsia, HELLP syndrome, SGA newborns, placental abruption)

• OHSS (time of occurrence after ovarian stimulation, severity, estradiol levels pg/ml, treatment)

• VTE

  1. VTE venous thromboembolism, IUI intrauterine insemination, IVF in vitro fertilization, ICSI intracytoplasmic sperm injection, PL pregnancy loss, IUFD intrauterine fetal death, SGA small-for-gestational age, OHSS ovarian hyperstimulation syndrome