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Table 1 Inclusion and exclusion criteria of the OTTILIA and FIRST registries

From: Rationale and design of two prospective, multicenter, observational studies on reproductive outcome in women with recurrent failures after spontaneous or assisted conception: OTTILIA and FIRST registries

OTTILIA

FIRST

Inclusion criteria

 • Pregnancy confirmed by urine/blood pregnancy test or ultrasound examination

 • Previous recurrent otherwise unexplained PL

  ≥3 or 2 PL in the presence of at least 1 normal fetal karyotype

or

 • At least 1 previous IUFD

  A loss after 20 weeks of a morphologically normal fetus

• ART cycle at enrolment

First, second and third level ART cycles

• 2 or more implantation failures/losses of clinical pregnancies after ART (independently of the number of embryos transferred)

At least 2 previous cycles with negative pregnancy test and/or PL after a positive pregnancy test

Exclusion criteria

 • Personal history of venous and/or arterial thromboembolism

 • Allergy to LMWHs

 • Uterine abnormalities

 • Cervical incompetence

 • Chromosomal abnormalities in parents

 • Known hemorrhagic diathesis

• Uterine abnormalities

• Hydrosalpinx

• Chromosomal abnormalities in parents

• Known hemorrhagic diathesis

• Previous inclusion in the study

  1. PL pregnancy loss, IUFD intrauterine fetal death, ART assisted reproductive technologies, LMWHs low-molecular-weight heparins