OTTILIA | FIRST |
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Inclusion criteria | |
• Pregnancy confirmed by urine/blood pregnancy test or ultrasound examination • Previous recurrent otherwise unexplained PL ≥3 or 2 PL in the presence of at least 1 normal fetal karyotype or • At least 1 previous IUFD A loss after 20 weeks of a morphologically normal fetus | • ART cycle at enrolment First, second and third level ART cycles • 2 or more implantation failures/losses of clinical pregnancies after ART (independently of the number of embryos transferred) At least 2 previous cycles with negative pregnancy test and/or PL after a positive pregnancy test |
Exclusion criteria | |
• Personal history of venous and/or arterial thromboembolism • Allergy to LMWHs • Uterine abnormalities • Cervical incompetence • Chromosomal abnormalities in parents • Known hemorrhagic diathesis | • Uterine abnormalities • Hydrosalpinx • Chromosomal abnormalities in parents • Known hemorrhagic diathesis • Previous inclusion in the study |