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Table 2 Association between exposure to HPV Vaccination and spontaneous abortion

From: Peri-conceptional or pregnancy exposure of HPV vaccination and the risk of spontaneous abortion: a systematic review and meta-analysis

Vaccine Exposure windows Number of studies Vaccine exposure group (total, n) Vaccine exposure group (SA, n) Control group (total, n) Control group (SA, n) RR 95% CI I 2 RD (%) 95% CI (%) I 2
2vHPV Pre-90 days to pregnancy end 3 1176 155 4308 521 1.15 0.95–1.39 0.0 1.6 −0.8-4.1 0.0
Pre-45 days to pregnancy end 2 680 85 1046 99 1.28 0.96–1.70 0.0 2.7 −0.7-6.1 0.0
Pre-45 days to LMP 1 317 48 316 30 1.59 1.04–2.45 5.6 0.2–11.1
During pregnancy (0–12 GWs) 1 137 16 124 17 0.85 0.45–1.61 −2.0 −10.7-6.6
4vHPV Pre-45 days to pregnancy end 4 2557 238 4257 389 0.88 0.73–1.06 0.0 −1.3 −2.9-0.3 0.0
Pre-45 days to LMP 3 1199 141 2405 276 1.00 0.80–1.24 0.0 0.1 −2.5-2.7 0.0
During pregnancy 2 1358 97 2771 209 0.79 0.62–1.01 0.0 −1.8 −3.5-0.1 0.0
9vHPV Pre-30 days to first 30 days of pregnancy 1 97 17 1418 122 2.04 1.28–3.24 8.9 1.2–16.6
  1. 2vHPV bivalent HPV vaccine, 4vHPV quadrivalent HPV vaccine, 9vHPV nonavalent HPV vaccine, LMP Last menstrual period, SA Spontaneous abortion, RR Relative risk, RD Risk difference