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Table 4 Risk factors for the following specified neonatal outcomes considered as dependent variables: Fetal PVL and fetal IVH (3rd-4th degree). Possible risk factors were considered as independent variables. Univariate and multivariate (*) logistic regression analysis was performed. (#) p-value corrected for the false discovery rate test

From: Maternal age and the risk of adverse pregnancy outcomes: a retrospective cohort study

 

OR (CI95%)

p

OR (CI95%) (*)

p (*)

p(#)

Fetal PVL

 Maternal age > 40 years

3.29 (1.24–8.73)

< 0.05

3.32 (1.17–9.44)

< 0.05

0.056

 Nulliparous women

0.92 (0.43–1.99)

0.835

   

 Conception via assisted reproductive techniques

2.65 (0.36–19.65)

0.339

   

 Low schooling

2.15 (0.98–4.75)

0.057

1.22 (0.52–2.88)

0.650

0.754

 Sub-Saharian Africa/Arabian/Other origin

3.8 (1.65–8.75)

< 0.05

2.71 (1.07–6.82)

< 0.05

0.061

 PRHDs

6.54 (2.25–19.03)

< 0.05

1.06 (0.35–3.26)

0.920

0.918

 Gestational age at birth (weeks) (ŧ)

0.68 (0.63–0.72)

< 0.05

0.66 (0.6–0.73)

< 0.05

< 0.05

 Prenatal RDS prophylaxis (ŧ)

7.42 (4.95–11.13)

< 0.05

0.06 (0.00–1.00)

0.050

0.070

Fetal IVH (3rd-4th degree)

 Maternal age < 17 years or > 40 years

2.69 (1.31–5.53)

< 0.05

2.97 (1.24–7.14)

< 0.05

< 0.05

 Nulliparous women

1.49 (0.84–2.64)

0.17

   

 Conception via assisted reproductive techniques

2.61 (0.63–10.75)

0.185

   

 Low schooling

1.49 (0.83–2.68)

0.184

   

 Sub-Saharian Africa origin

2.86 (1.22–6.71)

< 0.05

1.59 (0.59–4.28)

0.360

0.481

 PRHDs

2.99 (1.08–8.33)

< 0.05

0.71 (0.24–2.1)

0.530

0.533

 Gestational age at birth (weeks)

0.62 (0.58–0.66)

< 0.05

0.62 (0.58–0.66)

< 0.05

< 0.05

  1. Acronyms: PRHD Pregnancy related hypertensive disorder, PVL Periventricular leucomalacia, RDS Respiratory distress syndrome, IVH Intraventricular hemorrhage. Interaction terms: (ŧ) Interaction term for gestational age at birth and prenatal RDS prophylaxis OR 1.12 (CI95% 1.02–1.23) (p < 0.05)