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Table 4 Risk factors for the following specified neonatal outcomes considered as dependent variables: Fetal PVL and fetal IVH (3rd-4th degree). Possible risk factors were considered as independent variables. Univariate and multivariate (*) logistic regression analysis was performed. (#) p-value corrected for the false discovery rate test

From: Maternal age and the risk of adverse pregnancy outcomes: a retrospective cohort study

  OR (CI95%) p OR (CI95%) (*) p (*) p(#)
Fetal PVL
 Maternal age > 40 years 3.29 (1.24–8.73) < 0.05 3.32 (1.17–9.44) < 0.05 0.056
 Nulliparous women 0.92 (0.43–1.99) 0.835    
 Conception via assisted reproductive techniques 2.65 (0.36–19.65) 0.339    
 Low schooling 2.15 (0.98–4.75) 0.057 1.22 (0.52–2.88) 0.650 0.754
 Sub-Saharian Africa/Arabian/Other origin 3.8 (1.65–8.75) < 0.05 2.71 (1.07–6.82) < 0.05 0.061
 PRHDs 6.54 (2.25–19.03) < 0.05 1.06 (0.35–3.26) 0.920 0.918
 Gestational age at birth (weeks) (ŧ) 0.68 (0.63–0.72) < 0.05 0.66 (0.6–0.73) < 0.05 < 0.05
 Prenatal RDS prophylaxis (ŧ) 7.42 (4.95–11.13) < 0.05 0.06 (0.00–1.00) 0.050 0.070
Fetal IVH (3rd-4th degree)
 Maternal age < 17 years or > 40 years 2.69 (1.31–5.53) < 0.05 2.97 (1.24–7.14) < 0.05 < 0.05
 Nulliparous women 1.49 (0.84–2.64) 0.17    
 Conception via assisted reproductive techniques 2.61 (0.63–10.75) 0.185    
 Low schooling 1.49 (0.83–2.68) 0.184    
 Sub-Saharian Africa origin 2.86 (1.22–6.71) < 0.05 1.59 (0.59–4.28) 0.360 0.481
 PRHDs 2.99 (1.08–8.33) < 0.05 0.71 (0.24–2.1) 0.530 0.533
 Gestational age at birth (weeks) 0.62 (0.58–0.66) < 0.05 0.62 (0.58–0.66) < 0.05 < 0.05
  1. Acronyms: PRHD Pregnancy related hypertensive disorder, PVL Periventricular leucomalacia, RDS Respiratory distress syndrome, IVH Intraventricular hemorrhage. Interaction terms: (ŧ) Interaction term for gestational age at birth and prenatal RDS prophylaxis OR 1.12 (CI95% 1.02–1.23) (p < 0.05)