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Table 1 Patient characteristics according to duration of ritodrine hydrochloride infusion

From: Inappropriate use of ritodrine hydrochloride for threatened preterm birth in Japan: a retrospective cohort study using a national inpatient database

 

Total

Duration of ritodrine hydrochloride infusion

P value

≤48 h

3–6 days

7–13 days

14–27 days

≥28 days

Number of patients

134,959

23,178

(17.2)

21,550

(16.0)

21,911

(16.2)

29,556

(21.9)

38,764

(28.7)

 

Age in years, mean (SD)

< 20

2833

545

(19.2)

521

(18.4)

521

(18.4)

576

(20.3)

670

(23.6)

< 0.001

20–24

12,399

2309

(18.6)

2213

(17.8)

2106

(17.0)

2755

(22.2)

3016

(24.3)

 

25–29

33,390

5657

(16.9)

5268

(15.8)

5451

(16.3)

7399

(22.2)

9615

(28.8)

 

30–34

46,216

7717

(16.7)

7209

(15.6)

7395

(16.0)

10,227

(22.1)

13,668

(29.6)

 

35–39

32,418

5522

(17.0)

5103

(15.7)

5223

(16.1)

6976

(21.5)

9594

(29.6)

 

≥40

7703

1428

(18.5)

1236

(16.0)

1215

(15.8)

1623

(21.1)

2201

(28.6)

 

BMI, kg/m2

< 18.5

94,611

15,022

(15.9)

14,588

(15.4)

15,256

(16.1)

21,124

(22.3)

28,621

(30.3)

< 0.001

18.5–24.9

6856

1182

(17.2)

983

(14.3)

1016

(14.8)

1366

(19.9)

2309

(33.7)

 

25.0–29.9

24,981

4938

(19.8)

4480

(17.9)

4230

(16.9)

5453

(21.8)

5880

(23.5)

 

≥30.0

5399

1306

(24.2)

1010

(18.7)

924

(17.1)

998

(18.5)

1161

(21.5)

 

Smoking

No

109,253

18,309

(16.8)

17,172

(15.7)

17,815

(16.3)

24,195

(22.1)

31,762

(29.1)

< 0.001

Yes

12,636

2305

(18.2)

2258

(17.9)

2073

(16.4)

2641

(20.9)

3359

(26.6)

 

Multiple births

No

120,943

21,562

(17.8)

20,230

(16.7)

20,137

(16.6)

25,989

(21.5)

33,025

(27.3)

< 0.001

Yes

14,016

1616

(11.5)

1320

(9.4)

1774

(12.7)

3567

(25.4)

5739

(40.9)

 

PROM

No

130,527

21,338

(16.3)

20,527

(15.7)

21,351

(16.4)

29,054

(22.3)

38,257

(29.3)

< 0.001

Yes

4432

1840

(41.5)

1023

(23.1)

560

(12.6)

502

(11.3)

507

(11.4)

 

Placenta previa

No

126,431

22,187

(17.5)

20,451

(16.2)

20,545

(16.2)

27,235

(21.5)

36,013

(28.5)

< 0.001

Yes

8528

991

(11.6)

1099

(12.9)

1366

(16.0)

2321

(27.2)

2751

(32.3)

 

Gestational age at admission in weeks, mean (SD)

30 (3.7)

31.1

(3.9)

30.7

(4.0)

31.1

(3.7)

30.7

(3.1)

27.9

(2.9)

< 0.001

  1. BMI body mass index, PROM premature rupture of membranes at admission, SD standard deviation