Table 3 Prevalence of major birth defect, ORs and 95% CIs of subfertile men compared with fertile men for major birth defects within ICSI (n = 28,137 cycles)
Type of major birth defect | ICSI | |||
|---|---|---|---|---|
n (%) | Crude OR (95% CI) | Adjusted OR (95% CI)c | ||
Fertile men (n = 13,777) | Subfertile men (n = 14,360) | |||
Any major anomaly | 156 (1.13) | 157 (1.1) | 0.97 (0.68 to 1.38) | 0.95 (0.67 to 1.35) |
Cardiovascular | ||||
Ventricular septal defect | 40 (0.29) | 43 (0.30) | 1.03 (0.58 to 1.83) | 1.12 (0.65 to 1.91) |
Atrial septal defect | 8 (0.06) | 7 (0.05) | 0.84 (0.36 to 1.94) | 0.75 (0.33 to 1.70) |
Tetralogy of Fallot | 2 (0.01) | 3 (0.02) | 1.44 (0.28 to 7.35) | 1.78 (0.32 to 9.92) |
Musculoskeletal | ||||
Omphalocele | 1 (0.01) | 2 (0.01) | 1.92 (0.17 to 21.6) | 1.36 (0.13 to 13.9) |
Gastroschisis | 0 (0) | 0 (0) | – | – |
Diaphragmatic hernia | 6 (0.04) | 3 (0.02) | 0.48 (0.13 to 1.83) | 0.49 (0.12 to 2.08) |
Polydactyly | 11 (0.08) | 5 (0.03) | 0.44 (0.16 to 1.19) | 0.37 (0.14 to 1.01) |
Syndactyly | 3 (0.02) | 3 (0.02) | 0.96 (0.21 to 4.40) | 0.87 (0.14 to 5.26) |
Urogenital | ||||
Hypospadiasa | 3 (0.02) | 10 (0.07) | 2.89 (1.002 to 8.33) | 2.65 (0.90 to 7.85) |
Gastrointestinal | ||||
Alimentary atresiab | 13 (0.09) | 15 (0.10) | 1.11 (0.52 to 2.35) | 0.96 (0.46 to 1.98) |
Esophageal atresia | 4 (0.03) | 4 (0.03) | 0.96 (0.24 to 3.90) | 0.66 (0.17 to 2.50) |
Atresia of small intestine | 2 (0.01) | 2 (0.01) | 0.96 (0.11 to 8.08) | 0.97 (0.14 to 6.82) |
Rectal and large intestinal atresia | 8 (0.06) | 9 (0.06) | 1.08 (0.41 to 2.86) | 0.99 (0.39 to 2.53) |
Central nervous system | ||||
Anencephaly | 5 (0.04) | 5 (0.03) | 0.96 (0.28 to 3.24) | 0.85 (0.22 to 3.27) |
Spina bifida | 7 (0.05) | 2 (0.01) | 0.27 (0.06 to 1.31) | 0.26 (0.06 to 1.11) |
Orofacial | ||||
Cleft lip with and without cleft palate | 12 (0.09) | 11 (0.08) | 0.88 (0.37 to 2.11) | 0.95 (0.40 to 2.25) |