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Table 3 Summary of meta-analysis results and subgroups analysis

From: Assisted reproductive technology and the risk of preeclampsia: an updated systematic review and meta-analysis

Groups Studies Test of association Heterogeneity
RR (95% CI) P value Model Z Chi square P value I square
Total studies 48 1.71 (1.11–2.62) 0.015 Random 2.44 26,313.92 < 0.001 99.8%
Subgroup analyses
Study design
 Cohort 43 1.73 (1.10–2.72) 0.018 Random 2.36 25,159.19 < 0.001 99.8%
 Case control 5 1.46 (0.97–2.20) 0.070 Random 1.81 28.38 < 0.001 85.9%
Time Period
 1999–2010 18 1.64 (1.31–2.05) < 0.001 Random 4.29 117.09 < 0.001 85.5%
 2010–2017 30 1.74 (0.97–3.09) 0.062 Random 1.87 25,671.51 < 0.001 99.9%
Region
 Asia 11 1.71 (1.53–1.92) < 0.001 Random 9.38 17.12 0.072 41.6%
 Europe 26 1.74 (0.95–3.21) 0.075 Random 1.78 25,090.51 < 0.001 99.9%
 America 11 1.78 (1.31–2.41) < 0.001 Random 3.70 52.30 < 0.001 80.9%
  1. RR Relative Risk, CI Confidence Interval