Skip to main content

Table 5 MSCs Outcome Table

From: Potential biological therapies for severe preeclampsia: a systematic review and meta-analysis

Reference

Population

Dose

Blood pressure (mmHg)

Proteinuria

 

MSC

Control

MSC

Control

MSC

Control

Fu, 2015 [12]

Rats treated with 2 mL endotoxin (n = 21)

MSCs suspended in 100 μL phosphate-buffered saline (2 × 106 cells/100 μL)

Nothing

Systolic DG8: 113 DG15: 124.5* DG19: 124.0*

Systolic DG8: 112 DG15: 131.0 DG19: 135.5

DG9: 3.15 mol/L DG16: 4.60 mol/L* DG20: 5.60 mol/L*

DG9: 3.20 mol/L DG16: 3.65 mol/L DG20: 3.90 mol/L

Liu, 2014 [32]

Mice injected with 107 activated Th1 cells at DG10.5 and DG12.5 (n = 24)

MSCs suspended in 100 mL of PBS (106 cells/100 mL) injected on DG 11.5 and DG 13.5

Nothing

Systolic DG14: 135**

Systolic DG14: 182

DG14: 750 mg/L

DG14: 750 mg/L

Wang, 2016 [33]

Pregnant rats treated with 1 μg/kg LPS solution (n = 21)

2 × 106 MSCs per rat

Nothing

Systolic DG12: 116.27 ± 0.61 DG15: 125.08 + 3.42 DG18: 124.29 ± 3.71*

Systolic DG12: 115.65 ± 1.15 DG15: 127.41 ± 3.25 DG18: 139.50 ± 2.38

DG13: 3.10 ± 0.71 mol/Ln DG16: 3.81 ± 0.70 mol/L DG19: 4.54 ± 0.64 mol/L*

DG13: 3.06 ± 0.50 mg DG16: 4.55 ± 0.57mgn DG19: 5.56 ± 1.22 mg

  1. RED: Approximate value obtained by graph extrapolation
  2. DG day of gestation, LPS Lipopolysaccharide, PBS phosphate buffered saline
  3. *Statistically significant at p < 0.05
  4. **Statistically significant at p < 0.01