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Table 4 A1M Outcome Table

From: Potential biological therapies for severe preeclampsia: a systematic review and meta-analysis

Reference

Population

Dose

Blood pressure (mmHg)

Proteinuria

 

A1M

Control

A1M

Control

A1M

Control

Erlandsson, 2014 [29]

STOX1 transgene mouse model (n = NR)

A1M injections from DG6

Placebo, buffer solution

Unknown. States that A1M significantly reduced hypertension throughout pregnancy.

N/A

Unknown. States that A1M significantly reduced proteinuria throughout pregnancy.

N/A

Naav, 2015 [30]

Rabbits infused with 20 mg/kg of HbF (n = 19)

6 mg/kg of A1M

Nothing

HbF didn’t increase BP

 

11 μg/mL of albumin*

57 μg/mL of albumin

Wester-Rosenlof, 2014 [11]

Ewes starved for 36 h (n = 11)

2 bolus doses of 1.8 mg A1M/kg body weight 2 h apart

2 separate 50 mL doses of buffer solution

MAP 36 h post treatment: 58.5*

MAP 36 h post treatment: 73.5

  
  1. RED: Approximate value obtained by graph extrapolation
  2. MAP mean arterial pressure, DG day of gestation, BP blood pressure
  3. *statistically significant at p < 0.05