Causes of secondary hypertension in pregnancy | Prevalence in pregnancy | Clinical features | Clinical Examination |
---|---|---|---|
Chronic kidney disease | 0.9% | Albuminuria,hypercreatinine,edema,hypertension | Screen albuminuria, serum creatinine and Renal ultrasound |
Pheochromocytoma | 0.007% | sustained or paroxysmal hypertension, palpitation, cardiomyopathy,impaired glucose tolerance | 24-h urinary fractionated metanephrines and catecholamines and plasma fractionated metanephrines; Using abdominal ultrasound or a non-contrast MRI for localization of tumor |
Primary aldosteronism | 0.6–0.8% | increased secretion of aldosterone, low plasma renin activity, and hypertension, hypokalemia. | increased Plasma aldosterone concentrations and suppressed plasma renin activity; Abdominal ultrasonography or MRI scan can be performed if there is high clinical suspicion for an adrenal mass. |
Renovascular hypertension (including fibromuscular dysplasia and Takayasu’s arteritis) | – | Hypertension at a young age(<35 years) with abdominal vascular murmurs | ultrasound examination, MRI, angiography |
Cushing’s syndrome | – | Weight gain, striae, Moon Face,facial acne,impaired glucose tolerance | 24 h urine free cortisol elevation, loss of circadian fluctuation in cortisol; Using abdominal ultrasound or a non-contrast MRI for localization of tumor |
obstructive sleep apnea | 4.9% | Snoring, hypertension | Polysomnography |
Other uncommon cause | Thyroid disease, maternal coarctation of aorta, systemic lupus erythematosus and other connective tissue disease |