Table 2 Multivariable logistic regression analysis of the association between homocysteine and any placenta-mediated complication ^a (759 events ^b), n = 7587

Homocysteine (linear)

0.0007

 5 μmol/L increase

1.629

(1.227, 2.161)

Age (restricted cubic spline, three knots)

 34 versus 27 years

1.187

(1.063, 1.325)

Race

 Caucasian versus others

0.644

(0.509, 0.814)

Education

 College/University completed versus less than completed

0.763

(0.630, 0.924)

Nulliparous

 Yes versus no

1.941

(1.636, 2.303)

Smoking

 No

Reference

 Second-hand

0705

(0.392, 1.268)

 Med/light smoker (< 10 cigarettes per day)

1.631

(1.228, 2.166)

 Heavy smoker (> 10 cigarettes per day)

1.921

(1.348, 2.737)

Diabetes

 Yes versus no

1.687

(1.041, 2.733)

BMI (restricted cubic spline, four knots)

 27.3 versus 21.1 kg/m²

1.057

(0.883, 1.265)

Hormonal birth control prior to conception

 No

Reference

 Oral

0.927

(0.784, 1.096)

 Injection or IUD

0.732

(0.436, 1.227)

Chronic hypertension

 Yes versus no

2.750

(1.687, 4.483)

History of PMC (Preeclampsia, placental abruption, IUGR, stillbirth, loss)

 Yes versus no

1.359

(1.073, 1.722)

Folic acid supplementation

 Yes versus no supplementation

0.943

(0.674, 1.320)

Serum folate (linear)

 45.1 versus 30.6 nmol/L

1.025

(0.949, 1.106)

Gestational age at blood work (restricted cubic spline, four knots)

 13.7 versus 12.4 weeks

0.939

(0.804, 1.095)