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Table 5 Prediction of common chromosome abnormalities [trisomies (T) 21, 18 and 13 and sex chromosome abnormalities] and atypical (or other) abnormalities by risk factors, including a risk of T21 > 1 in 100, a nuchal translucency (NT) ≥ 3.5 mm, a low pregnancy associated plasma protein A (PAPP-A) < 0.2 multiple of medians, and a high risk for both trisomy 21 and trisomy 18, after conventional screening

From: Factors associated with common and atypical chromosome abnormalities after positive combined first-trimester screening in Chinese women: a retrospective cohort study

 

Common abnormalities

Atypical abnormalities

Factors

Unadjusted OR (95% CI)

Adjusted OR (95% CI)

Unadjusted OR (95% CI)

Adjusted OR (95% CI)

High risk for both T21 and T18

38.50 (20.80–71.25)*

12.14 (6.01–24.53)*

1.70 (0.22–12.87)

0.17 (0.02–1.67)

Risk of T21 > 1 in 100

8.08 (4.84–13.49)*

5.51 (3.26–9.31)*

2.37 (0.99–5.67)

1.44 (0.56–3.70)

NT ≥ 3.5 mm,

8.99 (6.03–13.42)*

4.05 (2.56–6.41)*

6.58 (2.81–15.42)*

6.43 (2.70–15.33)*

Low PAPP-A

9.42 (5.46–16.23)*

4.49 (2.16–9.35)*

6.14 (2.02–18.67)*

4.74 (1.49–15.01)*

  1. OR odds ratio, CI confidence interval.
  2. *statistically significant (p < 0.05), unadjusted OR after univariate analysis, adjusted OR after multivariable binary logistic regression
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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