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Table 2 Primary and secondary outcomes among 4913 women randomized to one of three routes of oxytocin administration during the third stage of labor

From: Intramuscular injection, intravenous infusion, and intravenous bolus of oxytocin in the third stage of labor for prevention of postpartum hemorrhage: a three-arm randomized control trial

 

Comparison of IV infusion to IM injection

Comparison of IV bolus to IM injection

 

IM injection (n = 2104)

IV infusion (n = 2108)

Estimatea

(95% CI)

P value

IV bolus (n = 701)

Estimatea

(95% CI)

P value

Primary outcomes

Mean total blood loss (SD)

204 (117)

188 (90)

−5.9 (−8.5, −3.3) b

< 0.001

180 (104)

−11.1 (−14.7, −7.8) b

< 0.001

Blood loss ≥500 ml, % (n)

1.5 (32)

0.8 (16)

0.50 (0.27, 0.91)

0.023

1.0 (7)

0.66 (0.29, 1.48)

0.311

Secondary outcomes

Mean min to placenta delivery (SD)

6.0 (3.8)

6.2 (4.1)

5.2 (1.5, 9.0) b

0.006

5.6 (3.4)

−4.9 (−9.7, − 0.1)b

0.047

Postpartum blood loss, % (n)

N = 2104

N = 2108

 

N = 701

 

≥ 350 ml

7.7 (163)

4.4 (92)

0.56 (0.44, 0.72)

< 0.001

4.0 (28)

0.52 (0.35, 0.76)

0.001

≥ 1000 ml

0.4 (9)

0.2 (4)

0.44 (0.14, 1.44)

0.176

0.1 (1)

0.33 (0.04, 2.63)

0.297

PPH diagnosed, % (n)

1.1 (22)

0.6 (12)

0.54 (0.27, 1.10)

0.089

0.9 (6)

0.82 (0.33, 2.01)

0.662

PPH diagnosed + ≥500 ml blood loss, % (n)

1.0 (21)

0.5 (11)

0.52 (0.25, 1.08)

0.080

0.7 (5)

0.71 (0.27, 1.89)

0.498

Hemoglobin measuresc

N = 2094

N = 2103

 

N = 700

 

Change in Hb, mean (SD)

−0.54 (0.50)

− 0.54 (0.46)

0.02 (− 0.29, 0.35)b

0.876

−0.51 (0.45)

0.29 (− 0.16, 0.75)b

0.209

Drop in Hb ≥2 g/dl, % (n)

2.1 (44)

1.8 (38)

0.86 (0.56, 1.32)

0.491

1.4 (10)

0.68 (0.34, 1.34)

0.267

Additional interventions, % (n)

N = 2104

N = 2108

 

N = 701

 

Manual removal of placenta

2.9 (60)

2.4 (50)

0.83 (0.57, 1.20)

0.330

1.3 (9)

0.45 (0.22, 0.90)

0.024

Additional uterotonics

1.1 (23)

0.6 (13)

0.56 (0.29, 1.11)

0.098

1.0 (7)

0.91 (0.39, 2.11)

0.833

Blood transfusion

0.5 (10)

0.2 (5)

0.50 (0.17, 1.46)

0.204

0.1 (1)

0.30 (0.04, 2.34)

0.251

  1. aEstimate reflects relative risk (RR) generated from log-binomial regression, except where otherwise noted
  2. bEstimates reflect the percent change in the mean outcome over different treatment groups – these were generated using linear regression on the log-transformed outcome and then applying the eq. )β[exp(·100 − β1], where = the regression coefficient for the log-transformed outcome
  3. cExcludes women who received blood transfusion
  4. In bold: comparison statistically significant at p ≤ 0.0435
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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