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Table 1 Patient characteristics, pregnancy outcome parameters, and differences among women who received tocolytic therapy as recommended in the guidelines (EVB) and women who received tocolytic therapy tocolysis in contrast with these recommendations (nonEVB)

From: Differences between evidence-based recommendations and actual clinical practice regarding tocolysis: a prospective multicenter registry study

 

Total

EVB

nonEVB

p EVB vs nonEVB

Women (n)

309

93

198

 

Characteristics

 Maternal Age

30.78 ± 5.8

30.35 ± 6.0

30.93 ± 5.6

0.699a

 Maternal BMI

23.25 ± 4.7

23.25 ± 4.6

23.17 ± 4.8

0.676a

 Smoking in pregnancy

37 (12.0%)

14 (15.1%)

21 (10.6%)

0.371 b

 ART

58 (18.7%)

12 (12.9%)

34 (17.2%)

0.470b

 Parity

0.64 ± 0.9

0.72 ± 1.0

0.62 ± 0.9

0.372 a

 Multiple pregancy

85 (27.5%)

18 (19.4%)

57 (28.8%)

0.116b

 GA at 1st TL (weeks)

28 (25–31)

30 (27–32)

27 (24–30)

< 0.001a

Children (n)

395

111

265

 

Pregnancy Outcome

 GA at delivery (weeks)

35 (31–38)

38 (35–39)

34 (30–38)

< 0.001a

  < 28 + 0

31 (10.0%)

4 (4.3%)

23 (11.6%)

< 0.001a

 28 + 0–33 + 6

83 (26.9%)

10 (10.8%)

64 (32.3%)

 

  > 34 + 0

195 (63.1%)

79 (84.9%)

111 (56.1%)

 

Birth weight (g)

  < 1000

33 (8.4%)

2 (1.8%)

29 (11.1%)

< 0.001a

 1000–2000

117 (29.9%)

20 (18.2%)

82 (31.4%)

 

  > 2000

242 (61.7%)

88 (80%)

150 (57.5%)

 

 UApH

7.3 ± 0.2

7.29 ± 0.1

7.31 ± 0.2

0.562a

 Transfer ad NICU

203 (51.4%)

35 (31.5%)

153 (57.8%)

< 0.001b

  1. Notes: Categorical data are presented as the frequency and percentage (rounded). Continuous variables are expressed as the mean ± SD, ordinal variables as the median (IQR). Women who delivered within 48 h after beginning of tocolytic treatment (n = 18) were excluded from EVB vs nonEVB analysis
  2. BMI body mass index, PTB preterm birth, ART assisted reproductive technology, GA gestational age, TL treatment with tocolytics, UAPH PH value of the umbilical artery, NICU neonatal intensive care unit, EVB evidence based, non EVB not evidence based – as defined above
  3. aWilcoxon rank sum test
  4. bPearson’s Chi-squared test with Yates’ continuity correction