Effects of oxytocin and anaesthesia on vascular tone in pregnant women: a randomised double-blind placebo-controlled study using non-invasive pulse wave analysis

Rabow, Sofus; Hjorth, Ull; Schönbeck, Sofia; Olofsson, Per

doi:10.1186/s12884-018-2029-1

Table 4 Haemodynamic effects of 5 U (8.3 μg) oxytocin and placebo (NaCl) given intravenously to first trimester pregnant women undergoing surgical evacuation of the uterus. For explanation of time points T1 and T2, see text and Figs. 1 and 2

From: Effects of oxytocin and anaesthesia on vascular tone in pregnant women: a randomised double-blind placebo-controlled study using non-invasive pulse wave analysis

Variable	Effect of drug injection measured T1-T2
	Oxytocin (OP group) N = 24				Placebo (PO group) N = 26				Δ value^a P
	T1 value Mean ± SD Median (range)	T2 value Mean ± SD Median (range)	P ^b	Effect	T1 value Mean ± SD Median (range)	T2 value Mean ± SD Median (range)	P ^b	Effect	Δ value^a P
MAP (mmHg)	67 ± 10 65 (49, 89)	76 ± 12 76 (57, 97)	0.001	BP increase	64 ± 9 62 (52, 88)	73 ± 8 74 (57, 87)	0.0001	BP increase	0.61
HR (bpm)	64 ± 8 63 (48, 82)	68 ± 9 71 (53, 84)	0.011	HR increase	66 ± 9 65 (51, 84)	66 ± 8 65 (53, 82)	0.90	No change	0.020
ECG ST index	0.21 ± 0.24 0.30(−0.20, 0.60)	0.15 ± 0.19 0.10 (− 0.40, 0.60)	0.30	No change	0.19 ± 0.21 0.10 (− 0.30, 0.60)	0.33 ± 0.21 0.30 (0.00, 0.80)	0.0005	ST increase	0.0008
PH	5.3 ± 2.9 4.8 (0.8, 13.3)	9.6 ± 2.5 8.8 (6.1, 15.0)	< 0.0001	Peripheral vasodilation	5.3 ± 3.0 4.9 (1.8, 14.9)	9.9 ± 3.3 9.5 (4.9, 16,0)	< 0.0001	Peripheral vasodilation	0.45
ETc (ms)	360 ± 39 366 (245, 418)	381 ± 41 383 (267, 444)	0.021	Decreased afterload, decreased SVR, increased preload	362 ± 51 369 (165, 437)	356 ± 55 371 (156, 404)	0.70	No change	0.069
EEI	0.58 ± 0.19 0.58 (0.18, 0.93)	0.59 ± 0.16 0.60 (0.26, 0.77)	0.65	No change	0.61 ± 0.18 0.60 (0.31, 1.00)	0.53 ± 0.13 0.51 (0.36, 0.83)	0.12	No change	0.17
EEI@75	0.67 ± 0.18 0.66 (0.28, 0.98)	0.65 ± 0.16 0.67 (0.32, 0.95)	0.95	No change	0.69 ± 0.20 0.72 (0.32, 1.14)	0.61 ± 0.15 0.57 (0.41, 0.96)	0.23	No change	0.43
DI	0.65 ± 0.15 0.67 (0.36, 0.94)	0.55 ± 0.11 0.55 (0.33, 0.77)	0.001	Small-artery vasodilation	0.66 ± 0.13 0.66 (0.41, 0.92)	0.67 ± 0.14 0.66 (0.41, 0.99)	0.84	No change	0.015
DI@75	0.55 ± 0.14 0.57 (0.25, 0.77)	0.49 ± 0.11 0.50 (0.32, 0.65)	0.023	Small-artery vasodilation	0.58 ± 0.14 0.58 (0.28, 0.80)	0.59 ± 0.15 0.61 (0.22, 0.88)	0.97	No change	0.10
b/a	− 0.59 ± 0.16 − 0.54 (− 0.95, − 0.26)	−0.57 ± 0.13 − 0.57 (− 0.85, − 0.25)	0.74	No change	−0.62 ± 0.14 − 0.61 (− 1.02, − 0.40)	−0.56 ± 0.08 − 0.55 (− 0.78, − 0.39)	0.094	No change	0.19
d/a	−0.17 ± 0.14 − 0.14 (− 0.54, − 0.01)	− 0.20 ± 0.09 − 0.20 (− 0.39, − 0.08)	0.38	No change	−0.18 ± 0.14 − 0.18 (− 0.50, − 0.01)	− 0.23 ± 0.13 − 0.20 (− 0.76, − 0.08)	0.084	No change	0.84
AI	− 0.31 ± 0.29 − 0.38 (− 0.77, 0.21)	−0.27 ± 0.24 − 0.27 (− 0.63, 0.24)	0.99	No change	−0.32 ± 0.29 − 0.37 (− 0.70, 0.42)	−0.25 ± 0.20 − 0.30 (− 0.50, 0.25)	0.086	No change	0.27

OP group, women given oxytocin at first injection and placebo at second injection; PO group, women given placebo at first injection and oxytocin at second injection
^a) The Δ values are not shown, but represent the T2 value minus T1 value. P denotes significance of difference in Δ value between oxytocin and placebo injections, performed with the Mann-Whitney U test
^b) P denotes significance of difference between T1 and T2 values, performed with the Wilcoxon matched-pairs signed-ranks test

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