Table 3 Haemodynamic effects of general anaesthesia in first trimester pregnant women. For explanation of measurement points T0 and T1, see text and Fig. 2
Variable | Number of cases | Cardiovascular effect of anaesthesia measured T0-T1 | |||
|---|---|---|---|---|---|
T0 value Mean ± SD Median (range) | T1 value Mean ± SD Median (range) | Significance of difference (P) | Cardiovascular effect | ||
MAP (mmHg) | 49 | 85 ± 12 84 (65, 112) | 65 ± 9 64 (49, 89) | 0.0001 | Blood pressure drop |
HR (bpm) | 33 | 73 ± 14 70 (44, 96) | 65 ± 9 63 (48, 84) | 0.002 | Heart rate drop |
ECG ST index | 48 | 0.15 ± 0.28 0.20 (− 0.70, 0.90) | 0.20 ± 0.22 0.20 (− 0.30, 0.60) | 0.13 | |
PH | 33 | 2.0 ± 1.9 1.3 (0.6, 10.5) | 5.3 ± 2.9 4.9 (0.8, 14.9) | 0.0001 | Peripheral vasodilation |
ETc (ms) | 33 | 374 ± 30 372 (313, 442) | 361 ± 45 368 (165, 437) | 0.56 | |
EEI | 27 | 0.69 ± 0.28 0.59 (0.27, 1.32) | 0.60 ± 0.18 0.58 (0.18, 1.00) | 0.19 | |
EEI@75 | 27 | 0.71 ± 0.26 0.74 (0.19, 1.21) | 0.68 ± 0.19 0.69 (0.28, 1.14) | 0.61 | |
DI | 33 | 0.66 ± 0.14 0.65 (0.37, 0.93) | 0.66 ± 0.14 0.66 (0.36, 0.94) | 0.31 | |
DI@75 | 33 | 0.65 ± 0.08 0.65 (0.50, 0.83) | 0.56 ± 0.14 0.58 (0.25, 0.80) | 0.0009 | Small-artery vasodilation |
b/a | 33 | −0.63 ± 0.14 − 0.64 (−1.05, − 0.39) | − 0.60 ± 0.15 − 0.56 (− 1.02, − 0.26) | 0.46 | |
d/a | 33 | − 0.20 ± 0.10 − 0.17 (− 0.49, − 0.07) | − 0.18 ± 0.14 − 0.15 (− 0.54, − 0.01) | 0.24 | |
AI | 33 | − 0.48 ± 0.30 − 0.53 (− 1.03, 0.24) | −0.32 ± 0.28 − 0.38 (− 0.77, 0.42) | 0.010 | Global vasoconstriction |