Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks’ gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study

Table 4 Diagnostic performance of sFlt-1:PlGF ratio ≥ 38 for preeclampsia, and < 10th and < 3rd centile infants

Outcome	Sensitivity	Specificity	PPV	NPV
Preeclampsia	66.7% [49.8–80.9%]	94.2% [90.1–97.0%]	31.8% [20.5–45.8%]	98.6% [97.8–99.1%]
Birthweight < 10th centile (All SGA)	24.5% [16.5–34.0%]	94.2% [90.1–97.0%]	32.4% [20.1–47.8%]	91.7% [90.7–92.5%]
Birthweight < 3rd centile (All SGA)	25.0% [10.7–44.9%]	89.3% [85.1–92.7%]	6.3% [3.2–12.3%]	97.6% [97.1–98.1%]

Data presented with [95% Confidence Interval]. NPV Negative Predictive value, PlGF placental growth factor, PPV Positive Predictive Value, sFlt-1 soluble fms-like tyrosine kinase-1, SGA small-for-gestational-age

ISSN: 1471-2393