Table 4 Antibiotic use in pregnancy and the risks of childhood asthma stratified by family history of allergic disorders
Exposure categories | Case N (%) | Control N (%) | OR (95% CI) | aORa (95% CI) |
|---|---|---|---|---|
Among children with family history of allergic disordersb (n = 507) | ||||
 No antibiotic use in pregnancy | 303 (90.7) | 168 (97.1) | ref | ref |
 Using antibiotics in pregnancy | 31 (9.3) | 5 (2.9) | 3.4 (1.3–9.0) | 3.1 (1.2–8.4) |
Among children without family history of allergic disordersb (n = 968) | ||||
 No antibiotic use in pregnancy | 275 (95.2) | 655 (96.5) | ref | ref |
 Using antibiotics in pregnancy | 14 (4.8) | 24 (3.5) | 1.4 (0.7–2.7) | 1.3 (0.6–2.6) |
Among children with Family history of allergic disorders | ||||
 Exclusively breastfed within the first 6 months of life (n = 252) | ||||
  No antibiotic use in pregnancy | 157 (94.6) | 82 (95.4) | ref | ref |
  Using antibiotics in pregnancy | 9 (5.4) | 4 (4.6) | 1.2 (0.4–3.9) | 0.8 (0.2–3.0) |
 Non - Exclusively breastfed within the first 6 months of life (n = 255) | ||||
  No antibiotic use in pregnancy | 146 (86.9) | 86 (98.9) | ref | ref |
  Using antibiotics in pregnancy | 22 (13.1) | 1 (1.1) | 13.0 (1.7–97.8) | 14.8 (1.9–116.8) |