Cost-effectiveness study | Cost-effectiveness of various prenatal tests in real clinical setting - In both low risk and high risk pregnancy - In both singleton and twin pregnancy |
Factors affecting the decision | 1) Questionnaire Study: factors affecting the decision on prenatal test by both participants, husbands and attending physicians in real clinical setting 2) Clinical factors affecting the decision in real clinical setting - In both low risk and high risk pregnancy - In both singleton and twin pregnancy |
NIPT | 1) Clinical aspect: Introduction of NIPT and its effects on selection of prenatal test including invasive diagnostic tests - In both low risk and high risk pregnancy - In both singleton and twin pregnancy 2) Diagnostic aspect: the diagnostic accuracy and no-call reports of NIPT - In both low risk and high risk pregnancy - In both singleton and twin pregnancy 3) The usefulness of NIPT in structural malformation or in increased nuchal translucency 4) The risk of major structural malformation according to the results of various prenatal tests |
Maternal serum screening | Evaluation of adverse pregnancy outcomes according to the maternal serum screening test - In both low risk and high risk pregnancy - In both singleton and twin pregnancy |
Invasive test study | 1) Complication rate including abortion in invasive prenatal tests in Korean clinical settings - In both low risk and high risk pregnancy - In both singleton and twin pregnancy 2) Change in abortion rate after the introduction of NIPT |
Guidelines | 1) Development of guidelines for prenatal screening test 2) Development of guidelines for prenatal diagnostic test |