Table 2 Impact of early hysterectomies due to bleeding on the effect of tranexamic acid
Exclusion interval (hours from randomisation) | Exclusionsa | N | Death due to bleeding | ||||
|---|---|---|---|---|---|---|---|
TXA (%) | Placebo (%) | TXA | Placebo | TXA (%) | Placebo (%) | Risk ratio (99% CI) | |
None | – | – | 7494 | 7384 | 188 (2.5) | 195 (2.6) | 0.95 (0.73–1.23) |
1 | 90 (1.2) | 93 (1.3) | 7404 | 7291 | 112 (1.5) | 117 (1.6) | 0.94 (0.67–1.32) |
2 | 175 (2.3) | 167 (2.3) | 7319 | 7217 | 42 (0.6) | 64 (0.9) | 0.65 (0.39–1.08) |
3 | 205 (2.7) | 214 (2.9) | 7289 | 7170 | 23 (0.3) | 34 (0.5) | 0.67 (0.33–1.33) |
4 | 217 (2.9) | 236 (3.2) | 7277 | 7148 | 19 (0.3) | 25 (0.4) | 0.75 (0.34–1.63) |
5 | 227 (3.0) | 246 (3.3) | 7267 | 7138 | 16 (0.2) | 20 (0.3) | 0.79 (0.33–1.86) |