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Table 4 Odds ratios and absolute risk of congenital malformation with sodium valproate (adapted from Jentink) [53]

From: Sodium valproate in pregnancy: what are the risks and should we use a shared decision-making approach?

Condition Odds ratio (median and range) in offspring of mothers who took valproate in pregnancy Absolute risk
Spina bifida 12.7 (7.7–20.7) 0.6%
Atrial septal defect 2.5 (1.4–4.4) 0.5%
Cleft palate 5.2 (2.8–9.9) 0.3%
Hypospadias 4.8 (2.9–8.1) 0.7%
Polydactyly 2.2 (1.0–4.5) 0.2%
Craniosynostosis 6.8 (1.8–18.8) 0.1%