Antidepressant use during pregnancy and the risk of developing gestational hypertension: a retrospective cohort study

Table 5 Association between the development of gestational hypertension after exposure of antidepressant in the series of additional sensitivity analyses

Outcome	Adjusted OR (95% CI)^a	P-value
Primary analysis
Antidepressant use
No exposure
Exposure	2.00 (1.28–3.13)	.002
Additional sensitivity analyses
Adjusted to calendar year*	1.70 (1.08–2.66)	.021
Alternative comparison regarding exposure**	1.45 (0.63–3.33)	.380
Exposure to at least two dispensing records^Ψ	2.19 (1.40–3.43)	.001
Exposure to at least two dispensing records^Ψ and adjusted to calendar year*	1.84 (1.17–2.89)	.008

OR, odds ratio
^aAdjusted for maternal age and medications use during pregnancy i.e. prescriptions of benzodiazepines and antibiotics
*Categorized into 1995–1999, 2000–2004, 2005–2009, and 2010–2015
**Women exposed to antidepressants between the theoretical conception date and 20 completed weeks of gestation were compared to women who were exposed to these drugs in the six-months period before theoretical conception date, but not during pregnancy
^ΨThe analysis was restricted to women having at least two dispensing records of an antidepressants from theoretical conception date until 20 completed weeks of gestation

ISSN: 1471-2393