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Table 4 Unadjusted and adjusted odds ratios for the development of gestational hypertension after exposure to antidepressant in the sensitivity analysis for the duration of gestation

From: Antidepressant use during pregnancy and the risk of developing gestational hypertension: a retrospective cohort study

Outcome

37 weeks

35 weeks

Unadjusted OR (95% CI)

Adjusted OR (95% CI)a

P-Value

Unadjusted OR (95% CI)

Adjusted OR (95% CI)a

P-value

Antidepressant use

 No exposure

–

–

–

–

–

–

 Exposure

2.13 (1.36–3.32)

2.17 (1.37–3,44)

.001

2.14 (1.34–3.42)

2.21 (1.37–3.58)

.001

Type of antidepressant

 TCAs

1.92 (0.60–6.11)

1,98 (0.62–6.34)

.252

2.20 (0.69–7.02)

2,31 (0.72–7.44)

.161

 SSRIs

2.15 (1.29–3.57)

2.14 (1.28–3.60)

.004

2.08 (1.21–3.57)

2.09 (1.20–3.64)

.009

 MAOI

–

–

–

–

–

–

 RIMA

–

–

–

–

–

–

 Other

1.62 (0.39–6.63)

1.64 (0.40–6.78)

.495

1.92 (0.47–7.92)

1.98 (0.48–8.23)

.348

DDD

  ≤ 30

0.72 (0.18–2.90)

0,79 (0.19–3.23)

.744

1.35 (0.43–4.27)

1.45 (0.46–4.62)

.529

  ≥ 30

2.68 (1.68–4.29)

2.65 (1.63–4.29)

<.001

2.41 (1.45–4.01)

2.44 (1.45–4.11)

.001

DDD SSRIs

  ≤ 30

0.54 (0.07–3.90)

0.59 (0.08–4.31)

.607

1.48 (0.36–6.06)

1.57 (0.38–6.49)

.532

  ≥ 30

2.68 (1.68–4.29)

2.65 (1.63–4.28)

.001

2,23 (1.24–3.99)

2.20 (1.21–3.98)

.010

Period

 0–10 weeks

2.21 (1.40–3.49)

2.25 (1.41–3.61)

.001

2.32 (1.43–3.74)

2.38 (1.46–3.90)

.001

 11–20 weeks

2.48 (1.47–4.20)

2.48 (1.45–4.26)

.001

2.42 (1.43–4.10)

2.44 (1.43–4.20)

.001

 0–10 weeks only

1.56 (0.69–3.54)

1.64 (0.71–3.74)

.242

1.50 (0.55–4.07)

1.59 (0.58–4.35)

.365

 Both periods (0–20 weeks)

2.69 (1.56–4.64)

2,69 (1.53–4.68)

.001

2.74 (1.59–4.73)

2.75 (1.58–4.82)

<.001

Maternal age

 15–19

–

–

–

–

–

–

 20–24

1.31 (0.18–9.68)

–

.790

1.77 (0.24–13.15)

–

.579

 25–29

1.97 (0.80–4.86)

–

.143

1.75 (0.64–4.78)

–

.278

 30–34

2,88 (1.49–5.53)

–

.002

2.89 (1.45–5.75)

–

.003

 34–39

1.29 (0.40–4.17)

–

.666

1.37 (0.42–4.41)

–

.600

 40+

1.30 (0.29–5.73)

–

.729

1.30 (0.29–5.73)

 

.729

  1. OR odds ratio, CI confidence interval, TCAs tricyclic antidepressants, SSRIs selective serotonin reuptake inhibitors, MAOI non-selective monoamine oxidase inhibitors, RIMA reversible inhibitors monoamine oxidase A, DDD defined daily dose
  2. aAdjusted for maternal age and medications use during pregnancy i.e. prescriptions of benzodiazepines and antibiotics