Table 2 Association between AED use during pregnancy and spontaneous abortion and pregnancy termination rates
From: Antiepileptic drug exposure in pregnancy and pregnancy outcome from national drug usage data
Spontaneous abortion | ||||
AED use | Spontaneous abortion | Total Pregnancies | Incidence ratea (95% CI) | Risk ratio (95% CI) |
AEDs | 255 | 2728 | 9.35 (8.31 to 10.50) | 1.48 (1.32–1.67) P < 0.0001 |
Age-adjusted rateb 8.97 (8.89 to 9.05) | Age adjusted risk ratiob 1.42 (1.40–1.44) P < 0.0001 | |||
No AEDs | 29,624 | 469,816 | 6.31 (6.24 to 6.38) | |
Pregnancy termination | ||||
AED use | Pregnancy termination | Total Pregnancies | Incidence ratea (95% CI) | Risk ratio (95% CI) |
AEDs | 496 | 2728 | 18.18 (16.78 to 19.67) | 0.93 (0.86–1.01) P = 0.0860 |
Age-adjusted rateb 18.51 (18.40 to 18.62) | Age adjusted risk ratiob 0.95 (0.94–0.96) P < 0.0001 | |||
No AEDs | 91,998 | 469,816 | 19.58 (19.47 to 19.70) | |