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Table 5 Results of the linear regression analysis modelling the association between pregnancies and the amount of iron removed by phlebotomies

From: Do pregnancies reduce iron overload in HFE hemochromatosis women? results from an observational prospective study

Variables

Univariable analysis

Multivariable analysis

e β

95% CI

P

e β

95% CI

P

No. of pregnancies

 0

1.00

  

1.00

  

 1 or 2

1.49

[0.98–2.26]

0.061

1.41

[0.99–2.02]

0.058

  ≥ 3

1.51

[0.99–2.31]

0.058

1.27

[0.89–1.83]

0.191

Age at diagnosis

  < 60 y.a

1.00

  

1.00

  

  ≥ 60 y.

1.19

[0.90–1.56]

0.214

1.11

[0.86–1.43]

0.415

Body mass index

  < 25 kg/m2

1.00

     

  ≥ 25 kg/m2

0.96

[0.72–1.27]

0.766

  

Alcohol intake

 Non excessive

1.00

  

1.00

  

 Excessiveb

2.29

[1.32–3.97]

0.004

1.32

[0.80–2.19]

0.279

Menopause

 No

1.00

  

1.00

  

 Yes

1.28

[0.97–1.71]

0.084

0.92

[0.72–1.19]

0.530

Regular blood donations

 No

1.00

     

 Yes

1.01

[0.76–1.34]

0.930

  

Chronic bleedings

 No

1.00

     

 Yes

1.01

[0.50–2.05]

0.979

  

Blood transfusions

 No

1.00

     

 Yes

0.98

[0.67–1.43]

0.924

  

Baseline ferritin

1.00

[1.00–1.00]

< 0.001

1.00

[1.00–1.00]

< 0.001

  1. aClassical cut-off for describing the beginning of the expression of HFE hemochromatosis in women
  2. bDaily consumption ≥2 glasses/day or 14 glasses/week in women (World Health Organization definition)
  3. Univariable analysis for pregnancy: global P-value = 0.140