Table 5 Accessibility, fetal fraction, and earliest gestational age at which cfDNA screening can be offered (n = 188)
Question: | OB/GYN (n = 114) % [95% CI] | MFM (n = 29) % [95% CI] | GP (n = 31) % [95%CI] | MW (n = 14) % [95% CI] | p-value |
|---|---|---|---|---|---|
Correctly identified that cfDNA is not widely accessible and free of cost to every woman in Canada. | 89.5% [82.3–94.0] | 89.7% [71.8–96.7] | 77.4% [59.1–89.0] | 85.7% [55.7–96.6] | p = 0.405 |
Correctly identified that 10 weeks is the earliest gestational age at which cfDNA can be offered. | 63.7% [54.4–72.1] | 100.0% | 54.8% [37.1–71.5] | 50.0% [25.1–74.9] | p = 0.036 |
Correctly identified the following factors as associated with low fetal fraction: | |||||
Maternal weight | 44.7% [35.8–54.0] | 75.9% [56.8–88.3] | 38.7% [23.2–57.0] | 21.4% [6.7–50.9] | p = 0.002 |
Crown-Rump Length | 14.0% [8.7–21.8] | 51.7% [33.7–69.3] | 9.7% [3.1–26.6] | 0.0% | p = 0.000 |
Gestational age | 64.9% [55.6–73.2] | 96.6% [78.4–99.5] | 41.9% [25.8–60.0] | 28.6% [10.6–57.3] | p = 0.000 |
Correctly identified the following factors as NOT associated with low fetal fraction: | |||||
Fetal sex | 97.4% [92.1–99.2] | 93.1% [75.6–98.3] | 96.8% [79.6–99.6] | 100.0% | p = 0.601 |
Parity | 99.1% [93.9–99.9] | 100.0% | 100.0% | 92.9% [60.8–99.1] | p = 0.133 |
Reported not knowing which factors are associated with low fetal fraction. | 27.2% [19.8–36.2] | 0.0% | 48.4% [31.3–65.8] | 64.3% [36.5–84.9] | p = 0.000 |