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Table 2 Outcomes at three months postpartum. “Intention to treat” model based analyses with early pregnancy (baseline) mean for all participants, and comparisons between groups at postpartum presented as mean, 95% confidence interval (CI) and p-value. Weight retention was estimated based both on the difference between postpartum weight and early pregnancy (baseline) weight, and between postpartum weight and self-reported pre-pregnancy weight

From: Exercise training during pregnancy reduces circulating insulin levels in overweight/obese women postpartum: secondary analysis of a randomised controlled trial (the ETIP trial)

Outcomes at postpartum

Baseline

Exercise Group (n = 36)

Control Group (n = 34)

Between-Group Comparison

Mean

95% CI

Mean

95% CI

Mean Diff

95% CI

p-value

Weight (kg)

96.8

96.0

92.7, 99.3

95.2

91.9, 98.5

0.82

−1.83, 3.46

0.54

PPWR1 (kg)a

 

- 0.8

−2.7, 1.1

−1.6

−3.5, 0.3

0.82

−1.83, 3.84

0.54

PPWR2 (kg)b

 

1.52

−0.73, 3.78

0.52

−1.82, 2.86

1.0

−2.15, 4.16

0.53

BMI (kg/m2)

34.5

34.2

33.2, 35.3

33.9

32.9, 35.0

0.29

−0.67, 1.25

0.55

Waist circumference (cm)

107.5

105.0

101.7, 108.2

102.9

99.6, 106.2

2.06

−1.34, 5.47

0.24

Body compositionc

 Fat mass (kg)

43.1

42.1

39.6, 44.6

42.0

39.5, 44.5

0.11

−2.05, 0.92

0.92

 Fat mass (%)

44.6

44.2

43.0, 45.5

43.9

42.7, 45.2

0.28

−0.83, 1.38

0.62

 Fat-free mass (kg)

52.7

52.1

50.4, 53.7

53.0

51.4, 54.7

−0.96

−2.83, 0.92

0.32

 Fat-free mass (%)

55.4

55.7

54.4, 57.1

56.4

55.1, 57.7

−0.65

−1.97, 0.67

0.33

Skinfold thickness

 Biceps area (mm)

21.1

16.7

14.7, 18.7

17.5

15.5, 19.6

−0.85

−3.15, 1.44

0.47

 Triceps area (mm)

30.0

26.4

24.4, 28.4

26.8

24.8, 28.8

−0.43

−2.67, 1.82

0.71

 Subscapular area (mm)

31.8

28.5

26.3, 30.8

30.0

27.7–32.3

−1.44

−4.03, 1.16

0.28

Blood pressure

 Systolic BP (mm/Hg)

124.5

120.6

117.5, 123.8

124.02

120.7, 127.4

−3.40

−7.70, −0.99

0.13

 Diastolic BP (mm/Hg)

76.0

75.8

73.3, 78.4

78.4

75.7, 81.1

−2.61

−6.19, 0.96

0.15

Blood measurements

 Fasting glucose (mmol/l)

4.7

5.1

4.9, 5.3

5.1

4.8, 5.26

0.02

−0.24, 0.27

0.91

 120-min glucose (mmol/l)

5.9

5.2

4.7, 5.8

5.8

5.3, 6.4

−0.60

−0.60, 1.31

0.10

 Insulin (pmol/l)

139.6

106.3

83.3, 129.2

141.4

118.1, 164.6

−35.10

−62.78, −7.15

0.01

 HbA1c (%)

5.2

5.3

5.2, 5.4

5.4

5.3, 5.5

−0.10

−0.25, 0.04

0.17

 Insulin C-peptide (nmol/l)

0.6

0.7

0.6, 0.8

0.7

0.6, 0.8

−0.01

−0.14, 0.11

0.82

 Triglycerides (mmol/l)

1.4

0.8

0.6, 1.0

1.0

0.8, 1.2

−0.21

−0.47, 0.05

0.12

 Ferritin (pmol/l)

127.0

69.9

56.0, 83.6

64.5

49.7, 79.1

5.46

−14.81, 25.71

0.60

 HDL cholesterol (mmol/l)

1.7

1.5

1.5, 1.6

1.5

1.4, 1.6

−0.02

−0.14, 0.11

0.81

 LDL cholesterol (mmol/l)

2.8

3.1

2.8, 3.4

3.2

2.8, 3.5

−0.08

−0.51, 0.34

0.71

 Total cholesterol (mmol/l)

5.0

4.9

4.5, 5.2

5.1

4.7, 5.4

−0.23

−0.71, 0.25

0.34

 Haemoglobin (g/l)

126.7

128.4

125.4, 131.5

129.7

126.5, 132.9

−1.30

−5.50, 2.90

0.56

 High-sensitive CRP (mg/l)

10.7

4.2

2.9, 5.6

4.8

3.4, 6.2

−0.58

−2.50, 1.34

0.55

 HOMA2-IR

2.5

3.5

2.5, 4.6

5.0

3.9, 6.0

−1.44

−2.89, 0.01

0.05

  1. Missing: The number of missing in the exercise group varied between 1and 5, in the control group between 1 and 3
  2. Statistics: The effect of treatment was assessed with linear mixed models. For the primary and secondary outcomes, the effect of time and treatment was taken as a fixed effect. Due to randomisation, no systematic differences between groups at baseline were assumed. Insulin was significantly lower (p = 0.01) in th exercise group postpartum
  3. Abbreviations: PPWR postpartum weight retention, BMI Body mass index, BP blood pressure, HbA1c Glycated Haemoglobin, HDL High-density lipoprotein, LDL Low-density lipoprotein, CRP C-reactive protein, HOMA2-IR homeostatic assessment of insulin resistance
  4. aPPWR1, postpartum weight minus weight at early pregnancy (baseline)
  5. bPPWR2, postpartum weight minus pre-pregnancy weight. Weight at pre-pregnancy was based on self-reported data. Mean pre-pregnancy weight for all participants were 94.4 kg
  6. cBody composition was measured by air displacement plethysmography (BOD POD)