Skip to main content

Table 3 Risk (OR) of specific congenital malformation if the mother had fever during 1st trimester of pregnancy

From: Fever in pregnancy and the risk of congenital malformations: a cohort study

  N
Cases
CRUDE OR
Fever in 1st Trimester
OR [95% CI]
ADJUSTEDa OR
Fever in 1st Trimester
OR [95% CI]
Type of Congenital Malformation
 Overall Malformationsb 2876 0.97 [0.86–1.10] 0.99 [0.88–1.12]
 Nervous system (DQ00 – DQ07) 114 0.46 [0.20–1.05] 0.47 [0.21–1.08]
 Eye, ear, face and neck (DQ10 – DQ18) 134 1.29 [0.78–2.12] 1.29 [0.79–2.10]
 Congenital heart defects (DQ20 – DQ26) 656 0.99 [0.77–1.27] 1.01 [0.79–1.29]
 Respiratory system (DQ30 – DQ34) 79 0.56 [0.23–1.39] 0.56 [0.23–1.39]
 Orofacial clefts (DQ35 – DQ37) 163 0.90 [0.54–1.51] 0.90 [0.54–1.50]
 Digestive system (DQ38 – DQ45, DQ790) 198 0.98 [0.63–1.55] 1.00 [0.63–1.56]
 Genital (DQ50 – DQ52,DQ54 – DQ56) 249 1.14 [0.78–1.67] 1.17 [0.79–1.71]
 Urinary (DQ60 – DQ64,DQ794) 231 0.58 [0.34–0.97] 0.58 [0.35–0.99]
 Limb and musculoskeletal (DQ650-DQ652,DQ58-DQ660, DQ681-DQ682, DQ688, DQ69 – DQ75, DQ761-DQ764, DQ766-DQ769, DQ77-DQ78, DQ796, DQ798-DQ799) 1157 1.04 [0.87–1.25] 1.06 [0.88–1.28]
 Other (DQ27-DQ28, DQ80-DQ85, DQ87, DQ89, DQ93, DQ99, DQ792, DQ793,DQ795) 297 1.00 [0.69–1.45] 1.01 [0.70–1.46]
  1. Classification of malformations with ICD-10 codes derived from EUROCAT
  2. The Danish National Birth Cohort 1996–2002
  3. aAdjusted for parity, spontaneous abortion, maternal age at conception, IVF, diabetes Mellitus, medical treatment of maternal epilepsy, rheumatoid arthritis, binge drinking in first trimester, smoking during pregnancy and socio-occupational status
  4. bCases with more than one malformation are only counted once in the “Overall malformations” subgroup