Fever in pregnancy and the risk of congenital malformations: a cohort study

Table 3 Risk (OR) of specific congenital malformation if the mother had fever during 1st trimester of pregnancy

	N Cases	CRUDE OR Fever in 1st Trimester OR [95% CI]	ADJUSTED^a OR Fever in 1st Trimester OR [95% CI]
Type of Congenital Malformation
Overall Malformations^b	2876	0.97 [0.86–1.10]	0.99 [0.88–1.12]
Nervous system (DQ00 – DQ07)	114	0.46 [0.20–1.05]	0.47 [0.21–1.08]
Eye, ear, face and neck (DQ10 – DQ18)	134	1.29 [0.78–2.12]	1.29 [0.79–2.10]
Congenital heart defects (DQ20 – DQ26)	656	0.99 [0.77–1.27]	1.01 [0.79–1.29]
Respiratory system (DQ30 – DQ34)	79	0.56 [0.23–1.39]	0.56 [0.23–1.39]
Orofacial clefts (DQ35 – DQ37)	163	0.90 [0.54–1.51]	0.90 [0.54–1.50]
Digestive system (DQ38 – DQ45, DQ790)	198	0.98 [0.63–1.55]	1.00 [0.63–1.56]
Genital (DQ50 – DQ52,DQ54 – DQ56)	249	1.14 [0.78–1.67]	1.17 [0.79–1.71]
Urinary (DQ60 – DQ64,DQ794)	231	0.58 [0.34–0.97]	0.58 [0.35–0.99]
Limb and musculoskeletal (DQ650-DQ652,DQ58-DQ660, DQ681-DQ682, DQ688, DQ69 – DQ75, DQ761-DQ764, DQ766-DQ769, DQ77-DQ78, DQ796, DQ798-DQ799)	1157	1.04 [0.87–1.25]	1.06 [0.88–1.28]
Other (DQ27-DQ28, DQ80-DQ85, DQ87, DQ89, DQ93, DQ99, DQ792, DQ793,DQ795)	297	1.00 [0.69–1.45]	1.01 [0.70–1.46]

Classification of malformations with ICD-10 codes derived from EUROCAT
The Danish National Birth Cohort 1996–2002
^aAdjusted for parity, spontaneous abortion, maternal age at conception, IVF, diabetes Mellitus, medical treatment of maternal epilepsy, rheumatoid arthritis, binge drinking in first trimester, smoking during pregnancy and socio-occupational status
^bCases with more than one malformation are only counted once in the “Overall malformations” subgroup

ISSN: 1471-2393