From: Fever in pregnancy and the risk of congenital malformations: a cohort study
Total | Fever in 1st trimester | No fever in 1st trimester | |||||
---|---|---|---|---|---|---|---|
N | % | PPa | N | % | N | % | |
Total study population | 77,344 | 100 | 3.7 | 8321 | 100 | 69,023 | 100 |
Parity | |||||||
0 | 36,017 | 46.6 | 4.1 | 3375 | 40.6 | 32,642 | 47.3 |
1 | 28,843 | 37.3 | 3.4 | 3502 | 42.1 | 25,341 | 36.7 |
2 | 10,159 | 13.1 | 3.4 | 1191 | 14.3 | 8968 | 13.0 |
≥ 3 | 2325 | 3.0 | 3.2 | 253 | 3.0 | 2072 | 3.0 |
Previous spontaneous abortion | |||||||
No | 62,570 | 80.9 | 3.7 | 6646 | 79.9 | 55,924 | 81.0 |
Yes | 14,774 | 19.1 | 3.8 | 1675 | 20.1 | 13,099 | 19.0 |
Maternal age at conception | |||||||
≤ 24 | 9656 | 12.5 | 3.7 | 1012 | 12.2 | 8644 | 12.5 |
25–29 | 32,370 | 41.9 | 3.8 | 3477 | 41.8 | 28,893 | 41.9 |
30–34 | 26,466 | 34.2 | 3.7 | 2940 | 35.3 | 23,526 | 34.1 |
≥ 35 | 8852 | 11.4 | 3.6 | 892 | 10.7 | 7960 | 11.5 |
In Vitro Fertilization | |||||||
No/Irrelevant | 75,646 | 97.8 | 3.7 | 8178 | 98.3 | 67,468 | 97.8 |
Yes | 1698 | 2.2 | 4.7 | 143 | 1.7 | 1555 | 2.3 |
Maternal diabetes | |||||||
No | 77,127 | 99.7 | 3.7 | 8285 | 99.6 | 68,842 | 99.7 |
Yes | 217 | 0.3 | 6.5 | 36 | 0.4 | 181 | 0.3 |
Medical treatment of maternal epilepsy | |||||||
No | 77,120 | 99.7 | 3.7 | 8306 | 99.8 | 68,814 | 99.7 |
Yes | 224 | 0.3 | 9.4 | 15 | 0.2 | 209 | 0.3 |
Maternal rheumatoid arthritis | |||||||
No | 77,243 | 99.9 | 3.7 | 8312 | 99.9 | 68,931 | 99.9 |
Yes | 101 | 0.1 | 8.9 | 9 | 0.1 | 92 | 0.1 |
Binge drinking in 1st trimester | |||||||
No | 59,006 | 76.3 | 3.7 | 6218 | 74.7 | 52,788 | 76.5 |
Yes | 18,338 | 23.7 | 3.8 | 2103 | 25.3 | 16,235 | 23.5 |
Smoking during pregnancy | |||||||
No | 57,719 | 74.6 | 3.7 | 6116 | 73.5 | 51,603 | 74.8 |
Yes | 19,625 | 25.4 | 3.8 | 2205 | 26.5 | 17,420 | 25.2 |
Socio-occupational status | |||||||
Higher grade professionals | 18,443 | 23.9 | 3.7 | 2118 | 25.5 | 16,325 | 23.7 |
Lower grade professionals | 24,247 | 31.4 | 3.6 | 2716 | 32.6 | 21,531 | 31.2 |
Skilled workers | 21,635 | 28.0 | 3.9 | 2127 | 25.6 | 19,508 | 28.3 |
Unskilled workers | 10,697 | 13.8 | 3.6 | 1084 | 13.0 | 9613 | 13.9 |
Students | 1782 | 2.3 | 4.3 | 217 | 2.6 | 1565 | 2.3 |
Unemployed >1 year | 540 | 0.7 | 4.3 | 59 | 0.7 | 481 | 0.7 |
Child sex | |||||||
Male | 39,546 | 51.1 | 4.0 | 4211 | 50.6 | 35,335 | 51.2 |
Female | 37,798 | 48.9 | 3.5 | 4110 | 49.4 | 33,688 | 48.8 |
Pre-conceptional intake of folic acid | |||||||
No | 67,892 | 87.8 | 3.7 | 7283 | 87.5 | 60,609 | 87.8 |
Yes | 9353 | 12.1 | 3.8 | 1029 | 12.4 | 8324 | 12.1 |
Total | 77,245 | 99.9 | 3.7 | 8312 | 99.9 | 68,933 | 99.9 |
Missing | 99 | 0.1 | 3.0 | 9 | 0.1 | 90 | 0.1 |
Antipyretic use in 1st trimester | |||||||
No | 65,205 | 84.3 | 3.8 | 6558 | 78.8 | 58,647 | 85.0 |
Yes | 11,982 | 15.5 | 3.5 | 1748 | 21.0 | 10,234 | 14.8 |
Missing | 157 | 0.2 | 4.5 | 15 | 0.2 | 142 | 0.2 |
Infections in 1st trimester | |||||||
No | 64,164 | 83.0 | 3.7 | 6012 | 72.2 | 58,152 | 84.3 |
Yes | 12,145 | 15.7 | 3.8 | 2196 | 26.4 | 9949 | 14.4 |
Missing | 1035 | 1.3 | 3.2 | 113 | 1.4 | 922 | 1.3 |