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Table 1 Characteristics of the 77,344 women with live-born singletons according to maternal fever in 1st trimester

From: Fever in pregnancy and the risk of congenital malformations: a cohort study

 

Total

Fever in 1st trimester

No fever in 1st trimester

 

N

%

PPa

N

%

N

%

Total study population

77,344

100

3.7

8321

100

69,023

100

Parity

 0

36,017

46.6

4.1

3375

40.6

32,642

47.3

 1

28,843

37.3

3.4

3502

42.1

25,341

36.7

 2

10,159

13.1

3.4

1191

14.3

8968

13.0

  ≥ 3

2325

3.0

3.2

253

3.0

2072

3.0

Previous spontaneous abortion

 No

62,570

80.9

3.7

6646

79.9

55,924

81.0

 Yes

14,774

19.1

3.8

1675

20.1

13,099

19.0

Maternal age at conception

  ≤ 24

9656

12.5

3.7

1012

12.2

8644

12.5

 25–29

32,370

41.9

3.8

3477

41.8

28,893

41.9

 30–34

26,466

34.2

3.7

2940

35.3

23,526

34.1

  ≥ 35

8852

11.4

3.6

892

10.7

7960

11.5

In Vitro Fertilization

 No/Irrelevant

75,646

97.8

3.7

8178

98.3

67,468

97.8

 Yes

1698

2.2

4.7

143

1.7

1555

2.3

Maternal diabetes

 No

77,127

99.7

3.7

8285

99.6

68,842

99.7

 Yes

217

0.3

6.5

36

0.4

181

0.3

Medical treatment of maternal epilepsy

 No

77,120

99.7

3.7

8306

99.8

68,814

99.7

 Yes

224

0.3

9.4

15

0.2

209

0.3

Maternal rheumatoid arthritis

 No

77,243

99.9

3.7

8312

99.9

68,931

99.9

 Yes

101

0.1

8.9

9

0.1

92

0.1

Binge drinking in 1st trimester

 No

59,006

76.3

3.7

6218

74.7

52,788

76.5

 Yes

18,338

23.7

3.8

2103

25.3

16,235

23.5

Smoking during pregnancy

 No

57,719

74.6

3.7

6116

73.5

51,603

74.8

 Yes

19,625

25.4

3.8

2205

26.5

17,420

25.2

Socio-occupational status

 Higher grade professionals

18,443

23.9

3.7

2118

25.5

16,325

23.7

 Lower grade professionals

24,247

31.4

3.6

2716

32.6

21,531

31.2

 Skilled workers

21,635

28.0

3.9

2127

25.6

19,508

28.3

 Unskilled workers

10,697

13.8

3.6

1084

13.0

9613

13.9

 Students

1782

2.3

4.3

217

2.6

1565

2.3

 Unemployed >1 year

540

0.7

4.3

59

0.7

481

0.7

Child sex

 Male

39,546

51.1

4.0

4211

50.6

35,335

51.2

 Female

37,798

48.9

3.5

4110

49.4

33,688

48.8

Pre-conceptional intake of folic acid

 No

67,892

87.8

3.7

7283

87.5

60,609

87.8

 Yes

9353

12.1

3.8

1029

12.4

8324

12.1

 Total

77,245

99.9

3.7

8312

99.9

68,933

99.9

 Missing

99

0.1

3.0

9

0.1

90

0.1

Antipyretic use in 1st trimester

 No

65,205

84.3

3.8

6558

78.8

58,647

85.0

 Yes

11,982

15.5

3.5

1748

21.0

10,234

14.8

 Missing

157

0.2

4.5

15

0.2

142

0.2

Infections in 1st trimester

 No

64,164

83.0

3.7

6012

72.2

58,152

84.3

 Yes

12,145

15.7

3.8

2196

26.4

9949

14.4

 Missing

1035

1.3

3.2

113

1.4

922

1.3

  1. The Danish National Birth Cohort 1996–2002
  2. aPP: Prevalence Proportion of overall congenital malformations per 100 live births