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Table 2 Associations of Pre-pregnancy BMI, Total GWG with the Risk of Preeclampsia and Subtypes (N = 9863)a,b

From: Pre-pregnancy BMI, gestational weight gain and risk of preeclampsia: a birth cohort study in Lanzhou, China

 

Control

PE

M-PE

S-PE

EOPE

LOPE

n = 9516

Cases n = 347

OR (95% CI)

Cases n = 141

OR (95% CI)

Case n = 206

OR (95% CI)

Case n = 43

OR (95% CI)

Case n = 304

OR (95% CI)

Pre-pregnancy BMI (kg/m2)

 Normal weight

6478

221

1.00

86

1.00

135

1.00

29

1.00

192

1.00

 Underweight

2058

46

0.76 (0.54–1.06)

24

1.00 (0.62–1.59)

22

0.60 (0.38–0.95)

4

0.49 (0.17–1.42)

42

0.80 (0.57–1.14)

 Overweight/obese

980

80

1.81 (1.37–2.39)

31

1.76 (1.14–2.71)

49

1.79 (1.26–2.54)

10

1.84 (0.87–3.90)

70

1.79 (1.33–2.41)

Total GWG (kg) by IOM Guidelines

 Adequate

3217

62

1.00

22

1.00

40

1.00

12

1.00

50

1.00

 Inadequate

1290

33

1.27 (0.82–1.96)

11

1.24 (0.59–2.57)

22

1.29 (0.75–2.19)

5

0.99 (0.34–2.85)

28

1.34 (0.83–2.15)

 Excessive

5009

252

2.28 (1.70–3.05)

108

2.79 (1.74–4.47)

144

2.03 (1.41–2.92)

26

1.23 (0.61–2.50)

226

2.53 (1.84–3.48)

Total GWG (kg) Change by quartilec

 GWG ≤ 13.5

2500

68

1.00

21

1.00

47

1.00

14

1.00

54

1.00

 13.5 < GWG ≤ 17

2711

55

0.85 (0.59–1.23)

21

1.03 (0.56–1.89)

34

0.78 (0.49–1.22)

4

0.30 (0.10–0.92)

51

0.99 (0.67–1.47)

 17 < GWG ≤ 20

2101

81

1.66 (1.18–2.33)

35

2.17 (1.25–3.78)

46

1.44 (0.94–2.20)

13

1.35 (0.62–2.93)

68

1.74 (1.20–2.52)

 20 < GWG

2204

143

2.59 (1.90–3.53)

64

3.55 (2.13–5.92)

79

2.17 (1.48–3.19)

12

1.17 (0.53–2.59)

131

2.95 (2.10–4.13)

Ptrend

  

<0.0001

 

<0.0001

 

<0.0001

 

0.357

 

<0.0001

  1. aPre-pregnancy BMI, total GWG and total GWG change were evaluated in separate models
  2. bAdjusted for maternal age, maternal employment during pregnancy, education level, monthly household income, newborn gender, parity, twin status, family history of hypertension; pre-pregnancy BMI and total GWG were mutually adjusted
  3. cDistribution of GWG based on quartile