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Table 3 Outcomes in a systematic review/meta-analyses on the safest mode of delivery for extremely preterm cephalic/non-cephalic twin pairs

From: What is the safest mode of delivery for extremely preterm cephalic/non-cephalic twin pairs? A systematic review and meta-analyses

Outcome GA category (weeks) Number of studies   CS (n/N) VD (n/N) OR (95% CI) for CS I2 (%) GRADE Quality of the evidence*
Neonatal death or Severe Brain Injury in survivors 24+0–27+6 2 First twin (cephalic) 1/6 4/8 OR 0.35 (0.00–92.61) 76 Very Low
Second twin (non-cephalic) 3/7 2/6 OR 1.69 (0.04–72.81) 55
Both twins 4/13 6/14 OR 0.83 (0.05–13.43) 56
Neonatal death 24+0–27+6 2 First twin (cephalic) 0/7 2/10 OR 0.36 (0.03–4.40) 0 Very low
Second twin (non-cephalic) 2/8 2/9 OR 1.31 (0.02–79.60) 66
Both twins 2/15 4/19 OR 0.73 (0.10–5.46) 26
Severe Brain Injury in survivors 24+0–27+6 2 First twin (cephalic) 1/6 2/6 OR 0.59 (0.00–154.35) 74 Very low
Second twin (non-cephalic) 1/5 0/4 OR 1.00 (0.02–40.28) N/A
Both twins 2/11 2/10 OR 0.76 (0.03–17.34) 48  
Respiratory distress syndrome (RDS) 25+0–27+6 2 First twin (cephalic) 13/14 15/15 OR 0.23 (0.01–6.25) N/A Very low
Second twin (non-cephalic) 13/14 13/15 OR 1.60 (0.12–20.99) N/A
Both twins 26/28 28/30 OR 0.77 (0.10–5.87) 0
  1. GA gestational age, CS caesarean section, VD vaginal delivery, n number of cases within exposure group, N total number in exposure group, OR odds ratio, CI confidence interval, Severe Brain Injury defined as intraventricular hemorrhage grade ≥ 3 or periventricular leukomalacia, N/A not applicable. *Based on the Grading of Recommendations Assessment, Development and Evaluation quality of evidence assessment (GRADE) approach